PROPHYLACTIC AND THERAPEUTIC VACCINATION AGAINST A MUCOSAL PAPILLOMAVIRUS
PROPHYLACTIC AND THERAPEUTIC VACCINATION AGAINST A MUCOSAL PAPILLOMAVIRUS
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DOI：
10.1099/0022-1317-74-6-945
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发表时间：
1993-06-01
影响因子：
3.8
通讯作者：
JARRETT, WFH
中科院分区：
文献类型：
--
作者：
CAMPO, MS;GRINDLAY, GJ;JARRETT, WFH
乳头瘤病毒是一种普遍存在的DNA病毒，可感染人类和动物，并引起多种粘膜和皮肤上皮肿瘤。这些病变中的一些，特别是那些影响粘膜上皮的病变，可以进展为鳞状细胞癌。预防或治愈病毒感染将最终导致乳头瘤病毒相关癌症发病率的降低。使用重组蛋白质。我们已经开发了针对牛乳头瘤病毒4型（一种与牛消化道癌症有关的粘膜乳头瘤病毒）的预防性和治疗性疫苗，对于人粘膜乳头瘤病毒也存在类似的可能性。
Papillomaviruses are ubiquitous DNA viruses affecting humans and animals and causing a variety of tumours of mucosal and cutaneous epithelia. Some of these lesions, particularly those affecting mucosal epithelia, can progress to squamous cell carcinomas. Prevention or cure of viral infection would ultimately lead to a decrease in the incidence of papillomavirus-associated cancers. Using recombinant proteins. we have developed prophylactic and therapeutic vaccines against bovine papillomavirus type 4, a mucosal papillomavirus implicated in cancer of the alimentary canal in cattle, similar possibilities exist for the human mucosal papillomaviruses.