Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology.
Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology.
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DOI：
10.1039/d0cc01581d
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发表时间：
2020-04
影响因子：
4.9
通讯作者：
Michael P. O’Hagan;J. Ramos‐Soriano;Susanta Haldar;Sadiyah Sheikh;Juan C. Morales;A. Mulholland;M. C. Galan
中科院分区：
文献类型：
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作者：
Michael P. O’Hagan;J. Ramos‐Soriano;Susanta Haldar;Sadiyah Sheikh;Juan C. Morales;A. Mulholland;M. C. Galan
我们报道了用二硫乙烯配体选择性靶向端粒G4 DNA，并展示了在与生理相关的条件下，可见光介导的G4配体结合模式和G-四元体结构的强大切换。配体对宫颈癌细胞的毒性受配体的光异构体状态的调节，首次表明G4有可能成为光药理策略的靶点。
We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.