Remembering one year later: Role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories
Remembering one year later: Role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories
复制标题
DOI：
10.1073/pnas.0409848102
复制
发表时间：
2005-02-15
影响因子：
11.1
通讯作者：
Cabeza, R
中科院分区：
文献类型：
--
作者：
Dolcos, F;LaBar, KS;Cabeza, R
情绪的记忆增强效果可以是强大而持久的。大多数研究调查这种现象的神经基础集中在编码和早期巩固过程，因此很少有人知道检索过程的贡献，特别是在长时间的保留间隔。为了解决这个问题，我们使用事件相关的功能磁共振成像来测量神经活动在检索的情绪和中性图片后，保留间隔1年。情绪和中性图片的检索活动分别分析成功（命中）与不成功（错过）检索项目和基于回忆与熟悉的反应。识别性能更好的情感比中性的图片，这种效果只被发现为基于回忆的反应。在杏仁核、内嗅皮层和海马体中，成功提取情绪图片比成功提取中性图片引起更大的活动。此外，在杏仁核和海马体中，情绪对回忆的影响大于对熟悉的影响，而在内嗅皮层中，这对两种形式的检索是相似的。这些发现阐明了杏仁核和内侧颞叶记忆区在长时间保持间隔后回忆和熟悉情绪记忆中的作用。
The memory-enhancing effect of emotion can be powerful and long-lasting. Most studies investigating the neural bases of this phenomenon have focused on encoding and early consolidation processes, and hence little is known regarding the contribution of retrieval processes, particularly after lengthy retention intervals. To address this issue, we used event-related functional MRI to measure neural activity during the retrieval of emotional and neutral pictures after a retention interval of 1 yr. Retrieval activity for emotional and neutral pictures was separately analyzed for successfully (hits) vs. unsuccessfully (misses) retrieved items and for responses based on recollection vs. familiarity. Recognition performance was better for emotional than for neutral pictures, and this effect was found only for recollection-based responses. Successful retrieval of emotional pictures elicited greater activity than successful retrieval of neutral pictures in the amygdala, entorhinal cortex, and hippocampus. Moreover, in the amygdala and hippocampus, the emotion effect was greater for recollection than for familiarity, whereas in the entorhinal cortex, it was similar for both forms of retrieval. These findings clarify the role of the amygdala and the medial temporal lobe memory regions in recollection and familiarity of emotional memory after lengthy retention intervals.