Powder Production and Particle Engineering for Dry Powder Inhaler Formulations
Powder Production and Particle Engineering for Dry Powder Inhaler Formulations
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DOI：
10.2174/1381612821666150820111134
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Zhou, Qi (Tony)
中科院分区：
文献类型：
--
作者：
Lin, Yu-Wei;Wong, Jennifer;Zhou, Qi (Tony)
干粉吸入器对于局部和全身有效药物的肺部递送已经变得越来越有吸引力。与液体对应物（例如雾化和加压定量吸入器）相比，粉末形式通常具有更好的化学稳定性、更好的便携性和潜在的上级患者依从性。目前，由于吸入器装置和制剂的设计差异，干粉吸入器之间的气雾剂性能在很大程度上变化。颗粒特性对颗粒间相互作用具有显著影响，其影响吸入粉末的雾化。在这篇综述中，关键的颗粒特性，影响气溶胶的性能进行了讨论。还评估了粉末生产和颗粒工程技术的最新进展，旨在开发新的吸入粉末制剂或提高现有产品的雾化效率。
Dry powder inhalers have become increasingly attractive for pulmonary delivery of locally and systemically effective medications. In comparison to the liquid counterparts, such as nebulisation and pressurised metered dose inhalers, the powder form generally offers better chemical stability, improved portability and potentially superior patient adherence. Currently, the aerosol performance between dry powder inhalers varies to a large extent due to differences in the design of inhaler device and formulation. The particulate properties have a significant influence on the inter-particle interactions, which impacts on the aerosolisation of the inhaled powder. In this review, critical particulate properties that affect aerosol performance are discussed. Recent advances in powder production and particle engineering techniques are also assessed, aiming to develop new inhaled powder formulations or improve the aerosolisation efficiency of existing products.