Multiple roles of alpha-smooth muscle actin in mechanotransduction.
Multiple roles of alpha-smooth muscle actin in mechanotransduction.
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DOI：
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发表时间：
2006
影响因子：
3.7
通讯作者：
Jiaxu Wang;R. Zohar;C. McCulloch
中科院分区：
文献类型：
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作者：
Jiaxu Wang;R. Zohar;C. McCulloch
α-平滑肌肌动蛋白（SMA）是一种有助于细胞产生机械张力的肌动蛋白亚型，通常仅限于血管平滑肌细胞，但SMA也可以在某些非肌肉细胞中表达，最值得注意的是肌成纤维细胞。这些细胞存在于愈合的伤口、疤痕和纤维收缩性病变中，在那里它们促成纤维化。在肌成纤维细胞中，与SMA相关的细胞产生的牵引力有助于基质重塑，但外源性机械力也可增加SMA表达。力诱导的SMA利用前馈放大环，其涉及局灶性粘连中的先验SMA、p38 MAP激酶与SMA细丝的结合、Rho的激活以及血清应答因子与SMA启动子的CArG-B盒的结合。因此，除了其作为组织重塑和收缩中的结构蛋白的重要性之外，SMA可以作为机械换能器，基于其物理连接机械感觉元件和增强其自身的力诱导表达的能力。
Alpha-smooth muscle actin (SMA), an actin isoform that contributes to cell-generated mechanical tension, is normally restricted to cells of vascular smooth muscle, but SMA can also be expressed in certain non-muscle cells, most notably myofibroblasts. These cells are present in healing wounds, scars, and fibrocontractive lesions where they contribute to fibrosis. In myofibroblasts, cell-generated traction forces associated with SMA contribute to matrix remodeling, but exogenous mechanical forces can also increase SMA expression. Force-induced SMA utilizes a feed-forward amplification loop involving a priori SMA in focal adhesions, the binding of the p38 MAP kinase to SMA filaments, activation of Rho and binding of serum response factor to the CArG-B box of the SMA promoter. Thus, in addition to its importance as a structural protein in tissue remodeling and contraction, SMA may serve as a mechanotransducer, based on its ability to physically link mechanosensory elements and to enhance its own, force-induced expression.