A new mechanism of blood vessel growth - hope for new treatment strategies.
A new mechanism of blood vessel growth - hope for new treatment strategies.
复制标题
血管生长的新机制——新治疗策略的希望。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
P. Gerwins
中科院分区：
文献类型：
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作者：
W. Kilarski;P. Gerwins
新血管的生长（血管生成）对于胚胎发育以及伤口愈合和许多疾病的进展是必不可少的，所述疾病例如癌症、炎性病症、眼病、牛皮癣和成人类风湿性关节炎。目前的范例完全通过萌芽血管生成或通过所谓的内陷性血管生成的血管分裂来解释血管生长。然而，这些机制主要来自于对发育中的胚胎的实验，而对成人中的血管生成知之甚少，例如，伤口愈合、肿瘤生长和炎症。最近，我们发现，成人血管生长可以由组织愈合或重塑过程中自然产生的机械力诱导和指导。与发芽和肠套叠相反，新的生物力学假设假设功能性血管被动移位，如果发现通用，可能会彻底改变在治疗各种疾病中开发抗血管生成和促血管生成疗法的方法。
Growth of new blood vessels (angiogenesis) is essential for embryo development as well as for wound healing and progression of a number of diseases such as cancer, inflammatory conditions, eye diseases, psoriasis, and rheumatoid arthritis in the adult. Current paradigms explain blood vessel growth entirely by sprouting angiogenesis or by vessel splitting through so called intussusceptive angiogenesis. However, these mechanisms are mainly derived from experiments on the developing embryo while less is known about angiogenesis in the adult during, e.g., wound healing, tumor growth, and inflammation. Recently we showed that blood vessel growth in the adult can be induced and directed by mechanical forces that naturally develop during healing or remodeling of tissues. In contrast to sprouting and intussusception, the new biomechanical hypothesis assumes that functional blood vessels are passively translocated which, if found generic, may drastically change the approach for developing anti- and pro-angiogenic therapies in the treatment of a variety of diseases.