Impact of Panic on Psychophysiological and Neural Reactivity to Unpredictable Threat in Depression and Anxiety.
Impact of Panic on Psychophysiological and Neural Reactivity to Unpredictable Threat in Depression and Anxiety.
复制标题
恐慌对抑郁和焦虑中不可预测威胁的心理生理和神经反应性的影响。
DOI：
10.1177/2167702616666507
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Phan KL
中科院分区：
文献类型：
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作者：
Lieberman L;Gorka SM;Shankman SA;Phan KL
对不可预测威胁的夸大焦虑反应（U型威胁）是惊恐障碍（PD）的核心特征。然而，目前尚不清楚这种异常是否特异于PD的诊断，或者是否会沿着一系列的惊恐障碍（PS）。此外，很少有人知道这种异常背后的神经过程中高PS。最后，没有研究测试惊吓增强和边缘神经反应性-U威胁反应性的常用指标-是否相关，因此反映了常见的异常。这些问题进行了调查，在42名成年人与一系列的PS。在受到惊吓的威胁期间，两次测量U威胁反应-一次是惊吓，一次是功能性磁共振成像（fMRI）。正如假设的那样，PS积极预测惊吓增强和dACC对U-威胁的反应性。惊吓增强和dACC激活U-威胁呈正相关。这些结果表明与PS相关的对U-威胁的异常反应的生物行为特征。
Exaggerated anxious responding to unpredictable threat (U-threat) is a core feature of panic disorder (PD). However, it is unknown whether this abnormality is specific to the diagnosis of PD or would manifest along a continuum of panic symptomatology (PS). Additionally, little is known about the neural processes underlying this abnormality among those high in PS. Finally, no studies have tested whether startle potentiation and limbic neural reactivity – commonly used indices of U-threat responsivity – are associated and therefore reflect common abnormalities. These questions were investigated in 42 adults with a range of PS. U-threat responding was measured twice during threat-of-shock – once with startle and once with functional magnetic resonance imaging (fMRI). As hypothesized, PS positively predicted startle potentiation and dACC reactivity to U-threat. Startle potentiation and dACC activation to U-threat were positively associated. These results suggest a biobehavioral profile of aberrant responding to U-threat associated with PS.