Phthalate metabolites in urine samples from Danish children and correlations with phthalates in dust samples from their homes and daycare centers
Phthalate metabolites in urine samples from Danish children and correlations with phthalates in dust samples from their homes and daycare centers
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DOI：
10.1016/j.ijheh.2013.03.014
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发表时间：
2014-01-01
影响因子：
6
通讯作者：
Clausen, Geo
中科院分区：
文献类型：
--
作者：
Langer, Sarka;Beko, Gabriel;Clausen, Geo
在世界各地，人类使用含有邻苯二甲酸盐的产品，而人类接触某些邻苯二甲酸盐会导致各种不良健康影响。本研究的目的是测定 441 名丹麦儿童（3-6 岁）尿液样本中邻苯二甲酸二乙酯 (DEP)、邻苯二甲酸二正丁酯 (DnBP)、邻苯二甲酸二异丁酯 (DiBP)、邻苯二甲酸丁苄酯 (BBzP) 和邻苯二甲酸二(2-乙基己基)酯 (DEHP) 代谢物的浓度。这些儿童是丹麦室内环境和儿童健康研究的对象。作为每个孩子体检的一部分，收集了他或她第一次晨尿的样本。随后分析这些样品中目标邻苯二甲酸盐的代谢物。每种代谢物的测量浓度近似呈对数正态分布，并且代谢物浓度彼此显着相关。此外，从儿童卧室和日托中心收集的灰尘中DEP、DnBP、DiBP和BBzP的质量分数与儿童尿液中这些邻苯二甲酸酯代谢物（分别为邻苯二甲酸单乙酯（MEP）、邻苯二甲酸单正丁酯（MnBP）、邻苯二甲酸单异丁酯（MiSP）和邻苯二甲酸单苄酯（MBzP））的浓度显着相关。这种相关性表明，室内暴露对丹麦儿童 DEP、DnBP、DiBP 和 BBzP 的摄入量有显着贡献。 DEHP 的情况并非如此。本研究中测得的邻苯二甲酸酯代谢物的尿液浓度与分布在四大洲的国家的儿童尿液样本中测得的浓度非常相似。这些相似之处反映了儿童接触含邻苯二甲酸盐产品的全球化。 (C) 2013 爱思唯尔有限公司。版权所有。
Around the world humans use products that contain phthalates, and human exposure to certain of these phthalates has been associated with various adverse health effects. The aim of the present study has been to determine the concentrations of the metabolites of diethyl phthalate (DEP), di(n-butyl) phthalate (DnBP), di(iso-butyl) phthalate (DiBP), butyl benzyl phthalate (BBzP) and di(2-ethylhexyl) phthalate (DEHP) in urine samples from 441 Danish children (3-6 years old). These children were subjects in the Danish Indoor Environment and Children's Health study. As part of each child's medical examination, a sample from his or her first morning urination was collected. These samples were subsequently analyzed for metabolites of the targeted phthalates. The measured concentrations of each metabolite were approximately log-normally distributed, and the metabolite concentrations significantly correlated with one another. Additionally, the mass fractions of DEP, DnBP, DiBP and BBzP in dust collected from the children's bedrooms and daycare centers significantly correlated with the concentrations of these phthalates' metabolites (monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiSP) and monobenzyl phthalate (MBzP), respectively) in the children's urine. Such correlations indicate that indoor exposures meaningfully contributed to the Danish children's intake of DEP, DnBP, DiBP and BBzP. This was not the case for DEHP. The urine concentrations of the phthalate metabolites measured in the present study were remarkably similar to those measured in urine samples from children living in countries distributed over four continents. These similarities reflect the globalization of children's exposure to phthalate containing products. (C) 2013 Elsevier GmbH. All rights reserved.