Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma?
Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma?
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DOI：
10.1136/thorax.58.1.14
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发表时间：
2003-01-01
期刊：
影响因子：
10
通讯作者：
Nishi, K
中科院分区：
文献类型：
--
作者：
Fujimura, M;Ogawa, H;Nishi, K
背景资料：我们描述了一组患者，他们表现为孤立的慢性支气管扩张剂耐药型干咳，伴有特应性体质、嗜酸性气管支气管炎和气道咳嗽受体超敏反应，无支气管高反应性，我们称之为“特应性咳嗽”。虽然咳嗽变异性哮喘虽然特应性咳嗽（其中咳嗽对支气管扩张剂有反应）被认为是典型哮喘的前兆，但尚不清楚特应性咳嗽是否也是哮喘的前兆。回顾性检查82例特应性咳嗽患者的典型哮喘发作情况，并与55例咳嗽变异性哮喘患者进行比较（20名未接受治疗的患者和35名接受长期吸入二丙酸倍氯米松（BDP）治疗的患者，218-467 μ g/天）。特应性咳嗽和咳嗽变异性哮喘的中位随访时间分别为4.8（1 ~ 11.5）年和3.7（1 ~ 12.4）年。在咳嗽变异性哮喘患者中，35例服用BDP的患者中有2例发生典型哮喘，20例未经治疗的患者中有6例发生典型哮喘（差异24.3%，95%CI 2.8 - 45.8，p
Background: We have described a group of patients who present with isolated chronic bronchodilator resistant non-productive cough with an atopic constitution, eosinophilic tracheobronchitis, and airway cough receptor hypersensitivity without bronchial hyperresponsiveness, which we have termed "atopic cough". Although cough variant asthma (in which the cough responds to bronchodilators) is recognised as a precursor of typical asthma, it is not known whether atopic cough is also a precursor of asthma.Methods: Eighty two patients with atopic cough were retrospectively examined for onset of typical asthma and compared with 55 patients with cough variant asthma (20 untreated patients and 35 treated with long term inhaled beclomethasone dipropionate (BDP), 218-467 mug/day). The median follow up period for patients with atopic cough and cough variant asthma was 4.8 (1-11.5) years and 3.7 (1-12.4) years, respectively.Results: Onset of typical asthma occurred in only one of the patients with atopic cough. In patients with cough variant asthma, typical asthma developed in two of 35 patients taking BDP and six of 20 untreated patients (difference 24.3%, 95% Cl 2.8 to 45.8, p