DURAMYCIN-B AND DURAMYCIN-C, 2 NEW LANTHIONINE CONTAINING ANTIBIOTICS AS INHIBITORS OF PHOSPHOLIPASE-A2 - STRUCTURAL REVISION OF DURAMYCIN AND CINNAMYCIN
DURAMYCIN-B AND DURAMYCIN-C, 2 NEW LANTHIONINE CONTAINING ANTIBIOTICS AS INHIBITORS OF PHOSPHOLIPASE-A2 - STRUCTURAL REVISION OF DURAMYCIN AND CINNAMYCIN
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DOI：
10.7164/antibiotics.43.1403
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发表时间：
1990-11-01
影响因子：
3.3
通讯作者：
PETER, HH
中科院分区：
文献类型：
--
作者：
FREDENHAGEN, A;FENDRICH, G;PETER, HH
耐久霉素 B 和 C 是两种新的含有羊毛硫氨酸的抗生素，已从链轮丝菌菌株 R2075 和灰色链霉菌 (R2107) 中分离出来。 已知的抗生素耐久霉素和肉桂霉素是从八条链轮丝菌 (DSM 40114) 和长孢黄链霉菌 (DSM 40165) 中重新分离出来的。 后两种化合物的结构应通过分别将氨基酸残基3改为谷氨酰胺和将17改为天冬酰胺来修改。因此，肉桂霉素似乎与Ro 09-0198相同。 白肽素已被证明与耐久霉素相同。 这些化合物的物理化学数据为所有耐久霉素抗生素具有相似的结构提供了证据。 该组的所有化合物均在 10(-6) 摩尔浓度下抑制人磷脂酶 A2。
Duramycins B and C, two new lanthionine containing antibiotics, have been isolated from Streptoverticillium strain R2075 and Streptomyces griseoluteus (R2107). The known antibiotics duramycin and cinnamycin were reisolated from Streptoverticillium hachijoense (DSM 40114) and Streptomyces longisporoflavus (DSM 40165). The structures of these latter two compounds should be revised by changing amino acid residue 3 to glutamine and 17 to asparagine, respectively.Cinnamycin therefore seems to be identical to Ro 09-0198. Leucopeptin has been shown to be identical to duramycin. Physico-chemical data of these compounds provide evidence for a similar structure for all duramycin antibiotics. All compounds of this group inhibit human phospholipase A2 at a concentration of 10(-6) molar.