Effects of chemotherapy and radiotherapy on spermatogenesis in humans.
Effects of chemotherapy and radiotherapy on spermatogenesis in humans.
复制标题
化学疗法和放疗对人类精子发生的影响。
DOI：
10.1016/j.fertnstert.2013.08.010
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发表时间：
2013-11
影响因子：
6.7
通讯作者：
Meistrich, Marvin L.
中科院分区：
文献类型：
--
作者：
Meistrich, Marvin L.
用化疗或放疗治疗癌症通常会导致精子数量减少至无精子水平，这种情况可能会持续数年或永久性。精子数量下降的时间过程可以通过生殖细胞的敏感性（其中分化精原细胞最敏感）以及已知的恢复动力学来预测。少精症或无精症的恢复变化较大，取决于干细胞是否被杀死以及通常支持干细胞分化的体细胞环境是否发生改变。在细胞毒性治疗剂中，放射线和大多数烷化药物最能有效地产生长期无精子症。大多数较新的生物靶向疗法，除了那些用于将放射性同位素或毒素靶向细胞的疗法外，似乎只有适度的效果，主要是对男性生殖系统的内分泌方面，但它们与细胞毒性药物联合使用时的效果尚未得到充分研究。
Treatment of cancer with chemo- or radiotherapy causes reduction of sperm counts often to azoospermic levels which may persist for several years or be permanent. The time course of declines in sperm count can be predicted by the sensitivity of germ cells, with differentiating spermatogonia being most sensitive, and the known kinetics of recovery. Recovery from oligoor azoospermia is more variable and depends on whether there is killing of stem cells and alteration of the somatic environment that normally supports differentiation of stem cells. Of the cytotoxic therapeutic agents, radiation and most alkylating drugs are the most potent at producing long-term azoospermia. Most of the newer biological targeted therapies, except those used to target radioisotopes or toxins to cells, seem to have only modest effects, mostly on the endocrine aspects of the male reproductive system, however their effects when used in combination with cytotoxic agents have not been well studied.
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影响因子：
9.3
作者：
Cremonesi, Marta;Ferrari, Mahila;Ferrucci, Pier Francesco
通讯作者：
Ferrucci, Pier Francesco
影响因子：
4
作者：
Focarelli, R;Francavilla, S;Rosati, F
通讯作者：
Rosati, F
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4.8
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通讯作者：
Holmes, J
影响因子：
45.3
作者：
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通讯作者：
Cortes, J
影响因子：
1.5
作者：
Hattori, Naoya;Gopal, Ajay K.;Rajendran, Joseph G.
通讯作者：
Rajendran, Joseph G.