IMITATE: An intensive computer-based treatment for aphasia based on action observation and imitation.
IMITATE: An intensive computer-based treatment for aphasia based on action observation and imitation.
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DOI：
10.1080/02687030802714157
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发表时间：
2010
期刊：
影响因子：
2
通讯作者：
Small SL
中科院分区：
文献类型：
--
作者：
Lee J;Fowler R;Rodney D;Cherney L;Small SL
来自灵长类动物的神经生理学证据表明，具有视觉和运动特性的镜像神经元的存在，在执行动作时和在观察相同动作时都会放电。观察-执行匹配的类似系统也可能存在于人类身上。我们推测，对顶叶-额叶系统的行为刺激可能在语言运动学习中发挥重要作用，从而帮助中风后的语言恢复。本文的目的是描述一个基于动作观察和模仿的计算机辅助失语治疗系统MIMATE的开发。我们还简要介绍了目前正在进行的随机对照临床试验，以评估其疗效和作用机制。模仿疗法包括静默观察六个不同说话者大声说出的视听单词和短语，然后在一段时间内参与者口头重复刺激。我们描述了治疗特征、刺激选择和治疗水平划分的基本原理。临床试验是一项随机的单盲对照试验，参与者接受两次治疗前基线评估，每隔六周，然后进行模拟或对照治疗。这两种疗法都是集中提供的(每天90分钟)。治疗后进行治疗后评估，并进行为期六周的随访评估。到目前为止，已经有五名参与者完成了模仿。我们预计随机对照试验的结果将于2010年底公布。模仿是一种新的计算机辅助失语症治疗方法，它得到了理论基础和先前的人类和灵长类神经生物学数据的支持。治疗是可行的，初步的行为数据正在浮现。然而，在临床试验数据完全评估模仿的疗效并从理论上了解人体镜子系统在失语症治疗中的作用机制和作用之前，结果还不能知道。
Neurophysiological evidence from primates has demonstrated the presence of mirror neurons, with visual and motor properties, that discharge both when an action is performed and during observation of the same action. A similar system for observation-execution matching may also exist in humans. We postulate that behavioral stimulation of this parietal-frontal system may play an important role in motor learning for speech and thereby aid language recovery after stroke. The purpose of this article is to describe the development of IMITATE, a computer-assisted system for aphasia therapy based on action observation and imitation. We also describe briefly the randomized controlled clinical trial that is currently underway to evaluate its efficacy and mechanism of action. IMITATE therapy consists of silent observation of audio-visually presented words and phrases spoken aloud by six different speakers, followed by a period during which the participant orally repeats the stimuli. We describe the rationale for the therapeutic features, stimulus selection, and delineation of treatment levels. The clinical trial is a randomized single blind controlled trial in which participants receive two pre-treatment baseline assessments, six weeks apart, followed by either IMITATE or a control therapy. Both treatments are provided intensively (90 minutes per day). Treatment is followed by a post-treatment assessment, and a six-week follow-up assessment. Thus far, five participants have completed IMITATE. We expect the results of the randomized controlled trial to be available by late 2010. IMITATE is a novel computer-assisted treatment for aphasia that is supported by theoretical rationales and previous human and primate data from neurobiology. The treatment is feasible, and preliminary behavioral data are emerging. However, the results will not be known until the clinical trial data are available to evaluate fully the efficacy of IMITATE and to inform theoretically about the mechanism of action and the role of a human mirror system in aphasia treatment.
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