Salivary pH: A diagnostic biomarker.
Salivary pH: A diagnostic biomarker.
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DOI：
10.4103/0972-124x.118317
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发表时间：
2013-07
影响因子：
--
通讯作者：
Kale R
中科院分区：
文献类型：
--
作者：
Baliga S;Muglikar S;Kale R
唾液中含有多种宿主防御因子。它影响牙石形成和牙周病。不同的研究已经完成，以找到唾液生物标志物与牙周病的确切相关性。由于生物标志物的多样性及其测定的复杂性，唾液pH值可尝试用作快速椅旁测试。本研究的目的是分析唾液的pH值，并确定其与牙周病严重程度的相关性。研究人群包括300例患者。他们被分为三组，每组100名患者：A组有临床健康的牙龈，B组有广泛的慢性牙龈炎和C组有广泛的慢性牙周炎。收集每例患者的随机未刺激唾液并检测pH值。采用方差分析技术对数据进行统计学分析。与对照组相比，泛发性慢性牙龈炎患者的唾液pH值更偏碱性（P = 0.001），而与泛发性慢性牙周炎患者的唾液pH值更偏酸性（P = 0.001）。这些结果表明，根据牙周状况的严重程度，pH值会发生显著变化。唾液pH值显示出显著的变化，因此与牙周病的严重程度相关。因此，唾液pH可用作快速椅旁诊断生物标志物。
Saliva contains a variety of host defense factors. It influences calculus formation and periodontal disease. Different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. With a multitude of biomarkers and complexities in their determination, the salivary pH may be tried to be used as a quick chairside test. The aim of this study was to analyze the pH of saliva and determine its relevance to the severity of periodontal disease. The study population consisted of 300 patients. They were divided into three groups of 100 patients each: Group A had clinically healthy gingiva, Group B who had generalized chronic gingivitis and Group C who had generalized chronic periodontitis. The randomized unstimulated saliva from each patient was collected and pH was tested. Data was analyzed statistically using analysis of variance technique. The salivary pH was more alkaline for patients with generalized chronic gingivitis as compared with the control group (P = 0.001) whereas patients with generalized chronic periodontitis had more acidic pH as compared with the control group (P = 0.001). These results indicate a significant change in the pH depending on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker.