Hydrogen donors and acceptors and basic amino acids jointly contribute to carcinogenesis
Hydrogen donors and acceptors and basic amino acids jointly contribute to carcinogenesis
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DOI：
10.1016/j.mehy.2016.11.014
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发表时间：
2017-01-01
影响因子：
4.7
通讯作者：
Liu, Qiuyun
中科院分区：
文献类型：
--
作者：
Tang, Man;Zhou, Yanchao;Liu, Qiuyun
A hypothesis is postulated that high content of hydrogen donors and acceptors, and basic amino acids cause the intracellular trapping of the H+ and Cl- ions, which increases cancer risks as local formation of HCI is mutagenic to DNA. Other cations such as Ca2+, and weak acids such as short-chain organic acids may attenuate the intracellular gathering of the H+ and Cl-, two of the most abundant ions in the cells. Current data on increased cancer risks in diabetic and obese patients are consistent with the assumption that hydrogen bonding propensity on glucose, triglycerides and other molecules is among the causative factors. (C) 2016 Elsevier Ltd. All rights reserved.
