Association between mammographic breast density and breast cancer tumor characteristics
Association between mammographic breast density and breast cancer tumor characteristics
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DOI：
10.1158/1055-9965.epi-04-0327
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发表时间：
2005-03-01
影响因子：
3.8
通讯作者：
Porter, PL
中科院分区：
文献类型：
--
作者：
Aiello, EJ;Buist, DSM;Porter, PL
目的：很少有研究探讨乳腺密度和乳腺癌肿瘤特征之间的关系。我们研究了乳腺癌患者的激素、增殖和组织学肿瘤特征与乳腺X线摄影乳腺密度之间的关系。我们对546名诊断为浸润性乳腺癌的妇女进行了横断面分析，以评估乳腺密度与肿瘤大小、淋巴结状态、淋巴或血管浸润、组织学分级、核分级、肿瘤分化、有丝分裂指数、肿瘤坏死、Ki-67增殖、雌激素受体、孕激素受体、p53、p27、细胞周期蛋白E、Bcl-2和C-erb-B2侵袭。对于无癌乳腺，乳腺密度被分类为脂肪（乳腺成像报告和数据系统代码1或2; n = 373）或致密（乳腺成像报告和数据系统代码3或4; n = 173）。一位病理学家测量了所有肿瘤标志物。结果：与肿瘤大小>1.0 cm的女性相比，肿瘤大小>1.0 cm的女性更有可能具有致密乳房。
Objectives: Few studies have examined the association between breast density and breast cancer tumor characteristics. We examined the association between hormonal, proliferative, and histologic tumor characteristics and mammographic breast density in women with breast cancer.Methods: We conducted a cross-sectional analysis in 546 women diagnosed with invasive breast cancer to evaluate the associations between breast density and tumor size, lymph node status, lymphatic or vascular invasion, histologic grade, nuclear grade, tumor differentiation, mitotic index, tumor necrosis, Ki-67 proliferation, estrogen receptor, progesterone receptor, p53, p27, cyclin E, Bcl-2, and C-erb-B2 invasion. Breast density was classified as fatty (Breast Imaging Reporting and Data System code 1 or 2; n = 373) or dense (Breast Imaging Reporting and Data System code 3 or 4; n = 173) for the cancer-free breast. A single pathologist measured all tumor markers. We examined whether the relationships were modified by interval cancer or screen-detected cancer.Results: Women with a tumor size >1.0 cm were more likely to have dense breasts compared with women with a tumor size