Galectin-1:: a key effector of regulation mediated by CD4+CD25+ T cells
Galectin-1:: a key effector of regulation mediated by CD4+CD25+ T cells
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DOI：
10.1182/blood-2006-04-016451
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发表时间：
2007-03-01
期刊：
影响因子：
20.3
通讯作者：
Lechler, Robert I.
中科院分区：
文献类型：
--
作者：
Garin, Marina I.;Chu, Chung-Ching;Lechler, Robert I.
已知天然存在的共表达CD 4和CD 25的专用调节性T细胞群体在维持外周T细胞耐受性中起关键作用;然而，它们的作用机制仍然不清楚。在这里，我们报告的β-半乳糖苷结合蛋白，半乳糖凝集素-1，家族的成员在调节性T细胞中过表达，并在激活后表达增加。最重要的是，半乳糖凝集素-1结合的阻断显著降低了人和小鼠CD 4（+）CD 25（+）T细胞的抑制作用。在从半乳糖凝集素-1纯合无效突变小鼠获得的CD 4（+）CD 25（+）T细胞中观察到调节活性降低。这些结果表明，半乳糖凝集素-1是这些细胞介导的调节的关键效应子。
The naturally occurring population of dedicated regulatory T cells that co-express CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of beta-galactoside-binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4(+)CD25(+) T cells. Reduced regulatory activity was observed in CD4(+)CD25(+) T cells obtained from galectin-1-homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells.