Reliability and validity of speech & pause measures during passage reading in ALS
Reliability and validity of speech & pause measures during passage reading in ALS
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DOI：
10.1080/21678421.2019.1697888
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发表时间：
2019-12-04
影响因子：
2.8
通讯作者：
Yunusova, Yana
中科院分区：
文献类型：
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作者：
Barnett, Carolina;Green, Jordan R.;Yunusova, Yana
目的：在肌萎缩侧索硬化症（ALS）的延髓疾病进展评估中，使用言语测量正在成为一种常见的做法。本研究旨在建立心理测量学特性（如可靠性，有效性，灵敏度，特异性）的语音和停顿时间的措施，在一个标准化的通道。研究方法：使用半自动方法（语音和语音分析，SPA）分析大量传代记录（ALS N = 775;神经典型对照N = 323）。结果：结果显示，控制参与者重复记录的语音和停顿措施的可靠性可接受。通过患者和对照组之间的显著组差异以及与总体ALS和延髓疾病严重程度的临床测量的相关统计，建立了强结构效度。说话率，暂停事件，和平均暂停持续时间能够检测ALS参与者在延髓疾病的症状前阶段具有良好的辨别能力（AUC 0.81）。结论：根据目前的心理测量评估，进行通道记录和语音和暂停时间分析被认为是有用的检测早期和渐进的变化与延髓ALS。
Objective: The use of speech measures is becoming a common practice in the assessment of bulbar disease progression in amyotrophic lateral sclerosis (ALS). This study aimed to establish psychometric properties (e.g. reliability, validity, sensitivity, specificity) of speech and pause timing measures during a standardized passage. Methods: A large number of passage recordings (ALS N = 775; Neurotypical controls N = 323) was analyzed using a semi-automatic method (Speech and Pause Analysis, SPA). Results: The results revealed acceptable reliability of the speech and pause measures across repeated recording by the control participants. Strong construct validity was established via significant group differences between patients and controls and correlation statistics with clinical measures of overall ALS and bulbar disease severity. Speaking rate, pause events, and mean pause duration were able to detect ALS participants at the presymptomatic stage of bulbar disease with a good discrimination ability (AUC 0.81). Conclusions: Based on the current psychometric evaluation, performing passage recording and speech and pause timing analysis was deemed useful for detecting early and progressive changes associated with bulbar ALS.