Effect of block compositions of amphiphilic block copolymers on the physicochemical properties of polymeric micelles
Effect of block compositions of amphiphilic block copolymers on the physicochemical properties of polymeric micelles
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DOI：
10.1016/j.polymer.2011.06.026
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发表时间：
2011-08-03
期刊：
影响因子：
4.6
通讯作者：
Okano, Teruo
中科院分区：
文献类型：
--
作者：
Li, Wei;Nakayama, Masamichi;Okano, Teruo
采用RAFT聚合法制备了不同链长的聚甲基丙烯酸正丁酯嵌段（PBMA）和聚n-丙烯酰啉嵌段（PAM）两亲性嵌段共聚物。嵌段聚合物在水中的填充参数（β < 0.2）表明形成了核-电晕结构，这从形成核和形成电晕的链表面积的差异进一步证实了这一点。水动力胶束大小与BMA （N-BMA）和AM （N-AM）的数量及其比值（N-BMA/N-AM）有关。随着N-BMA/N-AM值的增大，聚合物聚集数和内芯尺寸增大，临界胶束浓度、电晕厚度和嵌段共聚物胶束二次维里系数减小。这些性质随着N-BMA/N-AM值的增加而改变，导致电晕链单位密度（rho(AM)）的线性增加，从而限制了链的迁移率。因此，在低rho（AM）时，胶束与血清蛋白之间的相互作用在较高值时消失。因此，胶束性质和生物相容性都可以通过调整两亲性聚合物的嵌段组成来调节。(C) 2011 Elsevier Ltd.版权所有。
Amphiphilic block copolymers with various chain lengths of poly(n-butyl methacrylate) blocks (PBMA) and poly(N-acryloylmorpholine) blocks (PAM) were prepared by RAFT polymerization. Packing parameter of block polymers in water (beta < 0.2) indicated the formation of core-corona structures, which was further confirmed from a difference between core- and corona-forming chain surface areas. Hydrodynamic micellar size was related with the numbers of BMA (N-BMA) and AM (N-AM), and their ratios (N-BMA/N-AM). With increasing N-BMA/N-AM value, the polymer aggregation numbers and inner core sizes increased, while the critical micelle concentrations, the corona thickness, and the second virial coefficient of block copolymer micelles decreased. These properties changed with increasing N-BMA/N-AM value resulted in a linear increase in corona chain unit density (rho(AM)) that limited chain mobility. Thus, the interaction between the micelles and serum protein at low rho(AM) disappeared at a higher value. Consequently, both micellar properties and biocompatible effect can be regulated by tailoring the block compositions of amphiphilic polymers. (C) 2011 Elsevier Ltd. All rights reserved.