Origin and course of the coronary arteries in normal mice and in iv/iv mice
Origin and course of the coronary arteries in normal mice and in iv/iv mice
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DOI：
10.1046/j.1469-7580.2001.19940473.x
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发表时间：
2001-10-01
影响因子：
2.4
通讯作者：
Colvee, E
中科院分区：
文献类型：
--
作者：
Icardo, JM;Colvee, E
本文报道了正常小鼠和iv/iv品系小鼠冠状动脉的起源和分布。通过扫描电镜直接观察主动脉窦和血管腐蚀铸型检查研究冠状动脉。在正常小鼠中，左冠状动脉和右冠状动脉（LC、RC）分别从各自的Valsalva窦产生，并沿着心室边界行进到达心尖。冠状动脉沿着这条路线以直角或锐角发出小分支，供应心室。室间隔由隔动脉供应，隔动脉作为主分支起源于右冠状动脉。圆锥动脉起源于主冠状动脉干、隔动脉和/或直接来自主动脉。窦。血管铸型显示冠状动脉间病变。在84%的iv/iv小鼠中发现冠状动脉起源异常。这些异常包括双起点、高起点、裂缝样开口和存在单个冠状动脉开口。这些异常单独或以任何组合发生，并且与心脏部位无关。在大多数情况下，隔动脉起源于RC在孤立位，但主要起源于LC在反位心脏。除了这个异常的起源没有统计学相关性之间的冠状动脉异常和心脏部位或一个特定的模式异位。在iv/iv小鼠中观察到的冠状动脉异常与在人类心脏中发现的相似。大多数冠状动脉异常似乎是由于主动脉根和冠状动脉之间的连接缺陷。因此，iv/iv小鼠可构成研究人类心脏中类似异常发展的良好模型。
This paper reports on the origin and distribution of the coronary arteries in normal mice and in mice of the iv/iv strain, which show situs inversus and heterotaxia. The coronary arteries were studied by direct observation of the aortic sinuses with the scanning electron microscope, and by examination of vascular corrosion casts. In the normal mouse, the left and right coronaries (LC, RC) arise from the respective Valsalva sinus and course along the ventricular borders to reach the heart apex. Along this course the coronary arteries give off small branches at perpendicular or acute angles to supply the ventricles. The ventricular septum is supplied by the septal artery, which arises as a main branch from the right coronary. Conus arteries arise from the main coronary trunks, from the septal artery and/or directly from the Valsalva. sinus. The vascular casts demonstrate the presence of intercoronary anastomoses. The origin of the coronary arteries was found to be abnormal in 84% of the iv/iv mice. These anomalies included double origin, high take-off, slit-like openings and the presence of a single coronary orifice. These anomalies occurred singly or in any combination, and were independent of heart situs. The septal artery originated from RC in most cases of situs solitus but originated predominantly from LC in situs inversus hearts. Except for this anomalous origin no statistical correlation was found between the coronary anomalies and heart situs or a particular mode of heterotaxia. The coronary anomalies observed in the iv/iv mice are similar to those found in human hearts. Most coronary anomalies appear to be due to defective connections between the aortic root and the developing coronaries. iv/iv mice may therefore constitute a good model to study the development of similar anomalies in the human heart.