Mussel-Inspired, Injectable Polyurethane Tissue Adhesives Demonstrate In Situ Gel Formation under Mild Conditions
Mussel-Inspired, Injectable Polyurethane Tissue Adhesives Demonstrate In Situ Gel Formation under Mild Conditions
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受贻贝启发的可注射聚氨酯组织粘合剂在温和条件下展示原位凝胶形成
DOI：
10.1021/acsabm.1c00451
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发表时间：
2021
影响因子：
4.7
通讯作者：
Qiang Fu
中科院分区：
文献类型：
--
作者：
Xin Zhao;Hao Ming;Yanjun Wang;Feng Luo;Zhen Li;Jiyao Li;Hong Tan;Qiang Fu
组织粘合剂在外科伤口闭合和医疗装置的界面改性中被广泛期望。然而，传统粘合剂的粘合强度差、机械顺应性低、成本高和生物毒性限制了其生物医学应用。在这项工作中，我们制造了一类贻贝启发聚氨酯粘合剂（MPUAs）具有强大的性能，包括在温和条件下原位凝胶形成，复杂伤口的适应，强粘附性和良好的生物相容性。多巴胺修饰的赖氨酸（LDA），作为扩链剂，被引入到线性聚氨酯作为一个重要的粘合单元，和生物来源的赖氨酸被用作原位凝胶的温和固化剂。该预混聚氨酯胶粘剂可流畅地注入，并可填充不规则和复杂的缺陷。在混合几分钟后，粘合剂可以牢固地粘合多种基材，例如金属材料、有机材料和无机非金属材料。特别是，它们可以牢固地粘合新鲜（湿）生物组织，具有韧性界面，并且MPUA的搭接剪切强度（24.5 ± 2.0 kPa）是商业纤维蛋白胶的6倍。MPUA在猪主动脉上的爆破压为108.2 ± 3.8 mmHg，可满足大部分手术要求（≤20 mmHg）。由于其良好的生物相容性，该系统将提供潜在的应用在临床手术和医疗器械的生物涂层。
Tissue adhesives are widely desired in surgical wound closure and interfacial modification of medical devices. However, poor adhesive strength, low mechanical compliance, high costs, and biotoxicity of traditional adhesives limit their biomedical applications. In this work, we fabricated a class of mussel-inspired polyurethane adhesives (MPUAs) with robust properties, including in situ gel formation under mild conditions, accommodation of intricate wounds, strong adhesion, and good biocompatibility. Dopamine-modified lysine (LDA), as a chain extender, was incorporated into linear polyurethane as a crucial adhesive unit, and biologically sourced lysine was used as a mild curing agent for in situ gel. The premixed polyurethane adhesives can be fluently injected and can fill irregular and complicated defects. After mixing for several minutes, the adhesives can strongly bond multiple substrates, such as metallic materials, organic materials, and inorganic nonmetallic materials. In particular, they can strongly cohere the fresh (wet) biological tissues with a ductile interface, and the lap shear strength (24.5 ± 2.0 kPa) of the MPUAs was six times higher than that of the commercial fibrin glue. Moreover, the bursting pressure of MPUAs on the porcine aorta was 108.2 ± 3.8 mmHg, which can satisfy most of the surgical requirements (≤20 mmHg). Given its good biocompatibility, this system would provide potential applications in clinical surgery and biological coatings of medical devices.