Self-Regulating Model for Control of Replication Origin Firing in Budding Yeast
Self-Regulating Model for Control of Replication Origin Firing in Budding Yeast
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DOI：
10.4161/cc.2.6.596
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发表时间：
2003-01-01
期刊：
影响因子：
4.3
通讯作者：
Clarke, Duncan J.
中科院分区：
文献类型：
--
作者：
Diaz-Martinez, Laura;Clarke, Duncan J.
一个主要的研究领域集中在了解复制起始激发的调节上。现在人们认识到，检查点信号参与了这一受控过程，并且这种信号系统中的缺陷会影响基因组的完整性。复制起始放电的抑制在复制应激条件下最为明显，但起始起始放电也必须在每分钟的基础上进行调节，因为细胞通过不减弱的S期正常进行。在这里，我们总结了一个简单的模型来解释起源激发如何被自我调节系统控制。
A major research area concentrates on understanding the regulation of replication origin firing. It is now appreciated that checkpoint signaling participates in this controlled process and that defects in such signaling systems affect genome integrity. Inhibition of replication origin firing is most obviously apparent under conditions of replication stress, but origin firing must also be regulated on a minute-by-minute basis as cells progress normally through an unabated S-phase. Here we summarize a straightforward model to account for how origin firing could be controlled by a self-regulating system.