Cocaine-related attentional bias following trauma cue exposure among cocaine dependent in-patients with and without post-traumatic stress disorder.
Cocaine-related attentional bias following trauma cue exposure among cocaine dependent in-patients with and without post-traumatic stress disorder.
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在患有或不患有创伤后应激障碍的可卡因依赖住院患者中，创伤后与可卡因相关的注意偏差提示暴露。
DOI：
10.1111/j.1360-0443.2011.03508.x
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Lejuez,CarlW
中科院分区：
文献类型：
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作者：
Tull,MatthewT;McDermott,MichaelJ;Gratz,KimL;Coffey,ScottF;Lejuez,CarlW
虽然创伤后应激障碍（PTSD）和可卡因依赖的共同发生与广泛的负面临床结果相关，但对这种关联的机制知之甚少。本研究调查了一个潜在的机制-注意偏向可卡因图像后trauma cue exposure. Design男性和女性可卡因依赖的患者与PTSD和没有暴露于中性和个性化的创伤脚本在不同的日子，随后由视觉点探测任务。A 2（PTSD与非PTSD） × 2（中性与创伤脚本） × 2研究对象为60名创伤暴露的可卡因依赖住院患者，30例有PTSD，30例无PTSD史。测量使用视觉点探针任务评估注意力偏差，该任务描述了中性脚本和个性化创伤后可卡因相关的图像中性脚本曝光后，PTSD（与非PTSD）参与者表现出注意力偏离可卡因图像。这种效应在创伤脚本暴露后被逆转，PTSD参与者比非PTSD参与者对可卡因图像的位置表现出更大的注意力偏差。创伤脚本曝光后的主观痛苦的严重程度预测水平的注意力偏差PTSDparticipators. ConclusionsCoefficient似乎服务于创伤后应激障碍患者的情绪调节功能，并可能是一个潜在的目标简短的创伤后应激障碍物质使用障碍干预措施，可以促进住宅物质使用障碍治疗保留。
AimsAlthough the co‐occurrence of post‐traumatic stress disorder (PTSD) and cocaine dependence is associated with a wide range of negative clinical outcomes, little is known about the mechanisms that underlie this association. This study investigated one potential mechanism—attentional bias to cocaine imagery following trauma cue exposure.DesignMale and female cocaine‐dependent in‐patients with and without PTSD were exposed to both a neutral and personalized trauma script on separate days, followed by a visual dot‐probe task. A 2 (PTSD versus non‐PTSD) × 2 (neutral versus trauma script) × 2 (male versus female) design was used to examine hypotheses.SettingParticipants were recruited from a residential substance use disorder (SUD) treatment center.ParticipantsParticipants were 60 trauma‐exposed cocaine dependent in‐patients, 30 with current PTSD and 30 without a history of PTSD.MeasurementsAttentional bias was assessed using a visual dot‐probe task depicting cocaine‐related imagery following both a neutral script and personalized trauma script.FindingsFollowing neutral script exposure, PTSD (versus non‐PTSD) participants exhibited an attentional bias away from cocaine imagery. This effect was reversed following trauma script exposure, with PTSD participants exhibiting a greater attentional bias towards the location of cocaine imagery than non‐PTSD participants. Severity of subjective distress following trauma script exposure predicted level of attentional bias among PTSD participants.ConclusionsCocaine appears to serve an emotion‐regulating function among post‐traumatic stress disorder patients and may be a potential target for brief post‐traumatic stress disorder–substance use disorder interventions that can facilitate residential substance use disorder treatment retention.