Transdisciplinary approaches enhance the production of translational knowledge.
Transdisciplinary approaches enhance the production of translational knowledge.
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DOI：
10.1016/j.trsl.2016.11.002
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Williams SM
中科院分区：
文献类型：
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作者：
Ciesielski TH;Aldrich MC;Marsit CJ;Hiatt RA;Williams SM
转化研究的主要目标是产生和应用可以改善人类健康的知识。虽然在单一学科范围内进行的研究有助于我们在许多情况下实现这一目标，但当疾病病因复杂且卫生决策紧迫时，这种单学科方法可能不是最佳方法。为了解决这些问题，我们建议，跨学科的方法可以促进转化研究的进展，我们回顾出版物，证明这些方法可以看起来像什么。这些例子有助于1）证明为什么跨学科研究是有用的，2）激发关于如何进一步促进跨学科研究的对话。虽然我们注意到，开放的沟通是任何跨学科工作萌芽的先决条件，流行病学家可以在促进它方面发挥关键作用，但我们并没有提出进行跨学科研究的严格协议，因为真的不存在。这些成就是在典型的纪律和体制障碍可以克服的情况下取得的，但它们不是通过一个预先确定的计划实现的。跨学科交流的好处很难事先预测，详细的研究协议或过程可能会阻碍实现新的和重要的见解。总的来说，这些例子表明，加强跨学科信息交流可以作为一个起点，帮助研究人员更好地提出问题，整合更多相关证据，并更有效地推进翻译知识。具体来说，我们讨论了跨学科方法帮助我们更好地探索，评估和干预以改善人类健康的例子。
The primary goal of translational research is to generate and apply knowledge that can improve human health. Although research conducted within the confines of a single discipline has helped us to achieve this goal in many settings, this uni-disciplinary approach may not be optimal when disease causation is complex and health decisions are pressing. To address these issues, we suggest that transdisciplinary approaches can facilitate the progress of translational research, and we review publications that demonstrate what these approaches can look like. These examples serve to 1) demonstrate why transdisciplinary research is useful, and 2) stimulate a conversation about how it can be further promoted. While we note that open-minded communication is a prerequisite for germinating any transdisciplinary work and that epidemiologists can play a key role in promoting it, we do not propose a rigid protocol for conducting transdisciplinary research, as one really does not exist. These achievements were developed in settings where typical disciplinary and institutional barriers were surmountable, but they were not accomplished with a single predetermined plan. The benefits of cross-disciplinary communication are hard to predict a priori and a detailed research protocol or process may impede the realization of novel and important insights. Overall, these examples demonstrate that enhanced cross-disciplinary information exchange can serve as a starting point that helps researchers frame better questions, integrate more relevant evidence, and advance translational knowledge more effectively. Specifically we discuss examples where transdisciplinary approaches are helping us to better explore, assess, and intervene to improve human health.