Design and Rapid Prototyping of Thin-Film Laminate-Based Microfluidic Devices
Design and Rapid Prototyping of Thin-Film Laminate-Based Microfluidic Devices
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DOI：
10.1023/a:1012448412811
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发表时间：
2001-12-01
影响因子：
2.8
通讯作者：
Hayenga, Jon
中科院分区：
文献类型：
--
作者：
Weigl, Bernhard H.;Badrell, Ron;Hayenga, Jon
介绍了一种集成的微流控设计、建模和快速成型工艺。它是基于激光切割和层压的单个薄层塑料。该工艺允许快速和低成本地制造简单和复杂的三维微流体流动结构，这些结构通常在24小时内设计，制造和测试。它产生了微流控元件和系统，如混合器、分离器和检测器，以及完整的微流控集成电路，已用于复杂的生物样品，如全血。“主动”，机器控制的微流体一次性以及“被动”，不需要任何外部仪器的自包含卡片。这种设备包括一次性血液分析仪芯片，以及血液分离和分析工具。
An integrated microfluidic design, modeling, and rapid prototyping process is presented. It is based on laser cutting and lamination of individual thin layers of plastic. The process allows the rapid and low-cost manufacturing of both simple and complex 3-dimensional microfluidic flow structures that are routinely designed, fabricated, and tested within the space of 24 hours. It has yielded microfluidic elements and systems, such as mixers, separators, and detectors, as well as complete microfluidic integrated circuits that have been used with complex biological samples such as whole blood. Both "active", machine-controlled microfluidic disposables as well as "passive", self-contained cards that do not require any external instrument are presented. Such devices include a disposable hematology analyzer chip, as well as blood separation and analysis tools.