Organic plasma process for simple and substrate-independent surface modification of polymeric BioMEMS devices
Organic plasma process for simple and substrate-independent surface modification of polymeric BioMEMS devices
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DOI：
10.1016/j.bios.2004.01.003
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发表时间：
2004-07-15
影响因子：
12.6
通讯作者：
Karube, I
中科院分区：
文献类型：
--
作者：
Hiratsuka, A;Muguruma, H;Karube, I
采用有机等离子体聚合技术，通过气相沉积有机薄膜对聚合物基片表面进行改性，制备了聚合物生物微机电系统（BioMEMS）器件。该技术能够聚合沉积任何种类的单体，可用于在任何给定的化学惰性聚合物基底的表面上的防污涂层、润湿性控制或层与层界面产生的目的，而不涉及繁琐的表面有机反应。原型装置被制造成具有三电极配置的电化学葡萄糖生物传感器阵列，每个电极配置具有用于毛细管作用驱动的样品递送和相关酶促反应的微流体通道（500 μ m × 800 μ m）。强调使用聚合物衬底的等离子体聚合过程的优点，以及在我们的设备制造中完成的一些额外的功能，在聚合物BioMEMS领域的新的可能性进行了讨论。(C)2004 Elsevier B.V.保留所有权利。
A polymeric bio micro electromechanical systems (BioMEMS) device was fabricated using organic plasma polymerization, by which the surface of a polymeric substrate could easily be modified through vapor-phase deposition of organic thin films. This technique, capable of polymeric deposition of any kind of monomer, can serve the purpose of anti-fouling coating, wettability control, or layer-to-layer interface creation, on the surface of any given chemically-inert polymeric substrate without involving cumbersome surface organic reactions. A prototype device was fabricated to have an array of electrochemical glucose biosensors with the three electrode configuration, each of which has a microfluidic channel (500 mum x 800 mum) for capillary-action-driven sample delivery and the concerned enzymatic reaction. Stressing the advantages of the plasma polymerization process using a polymeric substrate together with some additional features accomplished in our device fabrication, new possibilities in the field of polymeric BioMEMS are discussed. (C) 2004 Elsevier B.V. All rights reserved.