Oral Toxicity of Indium in Rats: Single and 28‐Day Repeated Administration Studies
Oral Toxicity of Indium in Rats: Single and 28‐Day Repeated Administration Studies
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DOI：
10.1539/joh.l8070
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发表时间：
2008-11
影响因子：
3
通讯作者：
K. Asakura;H. Satoh;M. Chiba;Masahide Okamoto;K. Serizawa;M. Nakano;K. Omae
中科院分区：
文献类型：
--
作者：
K. Asakura;H. Satoh;M. Chiba;Masahide Okamoto;K. Serizawa;M. Nakano;K. Omae
铟在大鼠中的口服毒性：单次和28天重复给药研究：Keiko Asakura，et al.庆应义塾大学医学部预防医学和公共卫生部门-铟广泛用于电子工业，用于制造半导体，液晶面板和等离子显示面板，其产量正在增加。但是，有必要比以前更谨慎地处理，因为吸入铟的肺毒性已经确定。本研究的目的是通过口服给药和观察14天，以0或2，000 mg/kg的剂量单次给药后，表征铟的潜在毒性作用（急性经口毒性研究），并以每日0、40、200或1，000 mg/kg的剂量水平重复经口给药28天（28天重复经口给药毒性研究）。在急性经口给药毒性研究中，任何动物均未观察到死亡和临床体征、体重和尸检结果异常。此外，在28天重复经口给药毒性研究中，在高达1，000 mg/kg的剂量组中也未观察到铟相关变化。根据上述结果，在这些研究条件下，铟的半数致死剂量（LD 50）大于2，000 mg/kg，认为在这些条件下雄性和雌性动物的无明显不良作用水平（NOAEL）为1，000 mg/kg。
Oral Toxicity of Indium in Rats: Single and 28‐Day Repeated Administration Studies: Keiko Asakura, et al. Department of Preventive Medicine and Public Health, Keio University School of Medicine—Indium is widely used in the electronics industry to make semiconductors, liquid‐crystal panels, and plasma display panels, and its production is increasing. However, it is necessary to handle it more cautiously than before, because the pulmonary toxicity of inhaled indium has been identified. The present study aimed to characterize the potential toxic effects of indium through oral administration and observation for fourteen days following a single dose of 0 or 2,000 mg/kg (acute oral toxicity study), and repeated oral administration for 28 days at dose levels of 0, 40, 200, or 1,000 mg/kg daily (28‐day repeated oral dose toxicity study) to male and female Crj:CD (SD) IGS rats (SPF). No deaths and no abnormalities in clinical signs, body weights, and necropsy findings were observed for any of the animals in the acute oral toxicity study. Furthermore, no changes related to indium were also observed in the dose groups up to 1,000 mg/kg of the 28‐day repeated oral dose toxicity study. From the results described above, the lethal dose 50% (LD50) of indium is greater than 2,000 mg/kg under these study conditions, and the no‐observed‐adverse‐effect‐level (NOAEL) is considered to be 1,000 mg/kg for males and females under these conditions.