Pubertal development and regulation.
Pubertal development and regulation.
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DOI：
10.1016/s2213-8587(15)00418-0
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发表时间：
2016-03
影响因子：
44.5
通讯作者：
Kaiser, Ursula B.
中科院分区：
文献类型：
--
作者：
Abreu, Ana Paula;Kaiser, Ursula B.
青春期标志着童年的结束，是个体经历生理和心理变化以达到性成熟和生育能力的时期。下丘脑-垂体-性腺轴控制青春期和生殖，并受到一个复杂的兴奋和抑制因子网络的严格调节。这条轴在胚胎和出生后的早期阶段活跃，随后在童年时期受到抑制，在青春期开始时它的重新激活达到高潮。这种重新激活的机制尚不完全清楚。青春期开始的年龄因人而异，青春期开始的时间与成人生活中的几种健康结果有关。在本系列论文中，我们讨论了青春期标志，青春期开始的流行病学趋势，以及遗传，代谢和其他因素控制促性腺激素释放激素分泌以决定青春期开始的机制。
Puberty marks the end of childhood and is a period when individuals undergo physiological and psychological changes to achieve sexual maturation and fertility. The hypothalamic-pituitary-gonadal axis controls puberty and reproduction and is tightly regulated by a complex network of excitatory and inhibitory factors. This axis is active in the embryonic and early postnatal stages of life and is subsequently restrained during childhood, and its reactivation culminates in puberty initiation. The mechanisms underlying this reactivation are not completely known. The age of puberty onset varies between individuals and the timing of puberty initiation is associated with several health outcomes in adult life. In this Series paper, we discuss pubertal markers, epidemiological trends of puberty initiation over time, and the mechanisms whereby genetic, metabolic, and other factors control secretion of gonadotropin-releasing hormone to determine initiation of puberty.