Something from nothing: The evolution and utility of satellite repeats
Something from nothing: The evolution and utility of satellite repeats
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DOI：
10.1016/s0168-9525(98)01444-9
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发表时间：
1998-05-01
影响因子：
11.4
通讯作者：
Henikoff, S
中科院分区：
文献类型：
--
作者：
Csink, AK;Henikoff, S
复杂的真核生物的着丝粒周围有大块的串联重复序列或卫星。在果蝇的有丝分裂过程中，卫星DNA与蛋白质结合，而蛋白质在分裂间期又与其他位点结合。重复序列需要从有丝分裂时可用的蛋白质中借用伴侣蛋白质，这限制了可以扩展成大块的重复单元的范围。为了解释卫星的普遍存在和臂间定位，我们建议利用它们来维持晚期复制的区域，从而确保着丝粒是染色体上最后复制的区域。
Large blocks of tandemly repeated sequences, or satellites, surround the centromeres of complex eukaryotes. during mitosis in Drosophila, satellite DNA binds proteins that, during interphase, bind other sites. The requirement for a repeat to borrow a partner protein from those available at mitosis with limit the spectrum of repeat units that can be expanded into large blocks. To account for the ubiquity and pericentric localization of satellites, we propose that they are utilized to maintain regions of late replication, thus ensuring that the centromere is the last region to replicate on a chromosome.