Association of lipoproteins with cytokines and cytokine receptors in heart failure patients - Differences between ischaemic versus idiopathic cardiomyopathy
Association of lipoproteins with cytokines and cytokine receptors in heart failure patients - Differences between ischaemic versus idiopathic cardiomyopathy
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DOI：
10.1016/j.ehj.2003.09.023
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发表时间：
2003-12-01
影响因子：
39.3
通讯作者：
Vrints, CJ
中科院分区：
文献类型：
--
作者：
Conraads, VM;Bosmans, JM;Vrints, CJ
低总胆固醇预测慢性心力衰竭患者生存率低的观察结果质疑了降脂在这一人群中的有益作用。本研究探讨了冠心病（CAD）或特发性扩张型心肌病（IDCM）所致慢性心力衰竭患者脂蛋白浓度与白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α和可溶性TNF-α受体水平的关系。测定脂蛋白、IL-6、TNF-α、可溶性TNF-α受体1（sTNFR 1）和2（sTNFR 2）的血浆浓度。总胆固醇/HDL-胆固醇（CHOL/HDL）与TNF-α（r=0.24，P=0.035）、sTNFR 1（r=0.32，P=0.008）和sTNFR 2（r=0.37，P=0.002）水平相关。在CAD组中，CHOL/HDL和甘油三酯（TG）与sTNFR 2相关（CHOL/ HDL r=0.48，P=0.005，TG r=0.40，P=0.015）。IDCM患者的脂蛋白水平与细胞因子及sTNF-α受体水平无相关性（P>0.1）。结论冠心病心力衰竭患者的脂蛋白水平与炎症反应密切相关。IDCM患者的脂蛋白与细胞因子无相关性。(C)2003年欧洲心脏病学会。由Elsevier Ltd.出版，保留所有权利。
Aims The observation that tow total cholesterol predicted poor survival in patients with chronic heart failure, has questioned the beneficial effect of lipid-lowering in this population. This study investigated the relation between lipoprotein concentrations and the levels of interleukin (IL)-6, tumour necrosis factor (TNF)-alpha and the soluble TNF-alpha receptors in patients with chronic heart failure due to coronary artery disease (CAD) or idiopathic dilated cardiomyopathy (IDCM).Methods and results Seventy-one patients with chronic heart failure due to CAD (n=36) or IDCM (n=35) were enrolled. Plasma concentrations of lipoproteins, IL-6, TNF-alpha, soluble TNF-alpha receptor 1 (sTNFR1) and 2 (sTNFR2) were measured. Total cholesterol/HDL-cholesterol (CHOL/HDL) correlated with levels of TNF-alpha (r=0.24, P=0.035), sTNFR1 (r=0.32, P=0.008) and sTNFR2 (r=0.37, P=0.002). In the CAD group, CHOL/HDL and triglycerides (TG) correlated with sTNFR2 (r=0.48, P=0.005 for CHOL/ HDL, r=0.40, P=0.015 for TG). No relation was found between lipoproteins and cytokines or sTNF-alpha receptors for IDCM patients (P>0.1).Conclusion An atherogenic lipid profile favoured the inflammatory process in patients with heart failure due to CAD. No relation between lipoproteins and cytokines was detected in case of IDCM. (C) 2003 The European Society of Cardiology. Published by Elsevier Ltd. ALL rights reserved.