Controlled Cannabis Vaporizer Administration: Blood and Plasma Cannabinoids with and without Alcohol
Controlled Cannabis Vaporizer Administration: Blood and Plasma Cannabinoids with and without Alcohol
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DOI：
10.1373/clinchem.2015.238287
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发表时间：
2015-06-01
影响因子：
9.3
通讯作者：
Huestis, Marilyn A.
中科院分区：
文献类型：
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作者：
Hartman, Rebecca L.;Brown, Timothy L.;Huestis, Marilyn A.
背景技术：随着医疗和法律的大麻摄入量的增加，更多的人使用大麻汽化，更多的人在大麻的影响下驾驶。虽然同时使用Delta（9）-四氢大麻酚（THC）和酒精是常见的，但对潜在的药代动力学相互作用知之甚少。在这里，我们研究了血液和血浆汽化大麻素的处置，同时口服低剂量alcohol.METHODS：32成人大麻吸烟者（>= 1次/3个月，= 1 μ g/L，>= 16.7%的参与者保持阳性8.3小时postdose，而= 5 μ g/L。血液THC和11-OHTHC Cmax值与酒精的显着较高，可能解释了从大麻酒精组合观察到的性能损害增加。应仔细考虑所选的驾驶相关THC截止值，以最好地反映性能损害窗口。我们的研究结果将有助于促进法医解释，并为关于药物驾驶立法的辩论提供信息。(C)2015年美国临床化学协会
BACKGROUND: Increased medical and legal cannabis intake is accompanied by greater use of cannabis vaporization and more cases of driving under the influence of cannabis. Although simultaneous Delta(9)-tetrahydrocannabinol (THC) and alcohol use is frequent, potential pharmacokinetic interactions are poorly understood. Here we studied blood and plasma vaporized cannabinoid disposition, with and without simultaneous oral low-dose alcohol.METHODS: Thirty-two adult cannabis smokers (>= 1 time/3 months, = 1 mu g/L, >= 16.7% of participants remained positive 8.3 h postdose, whereas = 5 mu g/L.CONCLUSIONS: Vaporization is an effective THC delivery route. The significantly higher blood THC and 11-OHTHC Cmax values with alcohol possibly explain increased performance impairment observed from cannabisalcohol combinations. Chosen driving-related THC cutoffs should be considered carefully to best reflect performance impairment windows. Our results will help facilitate forensic interpretation and inform the debate on drugged driving legislation. (C) 2015 American Association for Clinical Chemistry