Coat as a dagger: the use of capsid proteins to perforate membranes during non-enveloped DNA viruses trafficking.

Coat as a dagger: the use of capsid proteins to perforate membranes during non-enveloped DNA viruses trafficking.
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DOI:
10.3390/v6072899
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发表时间:
2014-07-23
期刊:
Viruses
影响因子:
--
通讯作者:
Abrahamyan L
Abrahamyan L
中科院分区:
其他
文献类型:
--
作者:
Bilkova E;Forstova J;Abrahamyan L

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为了进入复制位点,小的非包膜DNA病毒必须使用有限数量的衣壳蛋白穿过细胞膜,衣壳蛋白也在细胞外环境中保护病毒基因组。大多数DNA病毒必须到达细胞核才能进行复制。参与跨膜渗透的衣壳蛋白在病毒的内体运输过程中暴露或释放。随后,衣壳蛋白的保守结构域与细胞膜相互作用并确保其有效渗透。本文综述了目前关于小的非包膜DNA病毒衣壳蛋白在感染早期细胞膜摄动中的作用的知识。
To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment. Most of DNA viruses have to reach the nucleus to replicate. The capsid proteins involved in transmembrane penetration are exposed or released during endosomal trafficking of the virus. Subsequently, the conserved domains of capsid proteins interact with cellular membranes and ensure their efficient permeabilization. This review summarizes our current knowledge concerning the role of capsid proteins of small non-enveloped DNA viruses in intracellular membrane perturbation in the early stages of infection.
腺病毒通过细胞质动力蛋白与病毒capsid己糖亚基的直接相互作用进行转运。
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