Metabolic syndrome in normal-weight Americans - New definition of the metabolically obese, normal-weight individual
Metabolic syndrome in normal-weight Americans - New definition of the metabolically obese, normal-weight individual
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DOI：
10.2337/diacare.27.9.2222
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发表时间：
2004-09-01
期刊：
影响因子：
16.2
通讯作者：
Heymsfield, SB
中科院分区：
文献类型：
--
作者：
St-Onge, MP;Janssen, I;Heymsfield, SB
目的：确定正常体重和轻度超重(BMI 18.5-26.9 kg/m(2))人群代谢综合征及其个体成分的患病率和可能性。研究设计和方法-第三次全国健康与营养检查调查，一项具有全国代表性的横断面调查，共有7602名成年人参加。根据国家胆固醇教育计划成人治疗小组III标准定义的代谢综合征的患病率和优势比(OR)是根据BMI中2.0到2.5个单位的增量计算的。结果-根据种族和性别的不同，代谢综合征的患病率从BMI 18.5-20.9 kg/m(2)的0.9-3.0%逐渐增加到BMI 25.0-26.9 kg/m(2)的9.6-22.5%。与BMI为18.5-20.9 kg/m(2)的男性相比，BMI为21-22.9 kg/m(2)的男性患代谢综合征的几率为4.13(95%CI 1.57-10.87)，BMI为23-24.9 kg/m(2)的男性为5.35(2.41-11.86)，BMI为25-26.9 kg/m(2)的男性为9.08(4.23-19.52)。酒精和总脂肪、饱和脂肪、碳水化合物和纤维的摄入量：女性相应的OR值分别为4.34(2.08-9.07)、7.77(3.95-15.26)和17.34(9.29-32.38)。结论--处于正常偏高体重和轻度超重BMI范围内的人有较高的患病率，患代谢综合征的风险增加。因此，对体重指数正常或轻微升高的个体进行筛查对于预防糖尿病和心血管疾病很重要。
OBJECTIVE - To determine the prevalence rates and likelihood of the metabolic syndrome and its individual components in normal-weight and slightly overweight individuals (BMI 18.5-26.9 kg/m(2)).RESEARCH DESIGN AND METHODS - There were a total of 7,602 adult participants of the Third National Health and Nutrition Examination Survey, a nationally representative cross-sectional survey. Prevalence and odds ratios (ORs) of the metabolic syndrome, defined according to National Cholesterol Education Program Adult Treatment Panel III criteria, were computed according to 2.0- to 2.5-unit increments in BMI.RESULTS - Depending on ethnicity and sex, the prevalence of the metabolic syndrome increased in a graded fashion from 0.9-3.0% at BMI 18.5-20.9 kg/m(2) to 9.6-22.5% at BMI 25.0-26.9 kg/m(2). Compared with men with BMI 18.5-20.9 kg/m(2), the odds for the metabolic syndrome were 4.13 (95% CI 1.57-10.87) for men with BMI 21-22.9 kg/m(2), 5.35 (2.41-11.86) for men with BMI 23-24.9 kg/m(2), and 9.08 (4.23-19.52) for men with BMI 25-26.9 kg/m(2) after controlling for age, ethnicity, education, income, physical activity, smoking status, and alcohol and total fat, saturated fat, carbohydrate, and fiber intakes: The corresponding ORs in women were 4.34 (2.08-9.07), 7.77 (3.95-15.26), and 17.34 (9.29-32.38).CONCLUSIONS - Individuals in the upper normal-weight and slightly overweight BMI range have a relatively high prevalence and are at increased risk of having the metabolic syndrome. Therefore, screening in individuals with normal or slightly elevated BMI is important in the prevention of diabetes and cardiovascular disease.