The effect of starvation and refeeding with oral versus intravenous glucose on serum 3,5-,3,3'-and 3'-5'-diiodothyronine and 3'-monoiodothyronine.
The effect of starvation and refeeding with oral versus intravenous glucose on serum 3,5-,3,3'-and 3'-5'-diiodothyronine and 3'-monoiodothyronine.
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饥饿和重新喂养口服葡萄糖与静脉注射葡萄糖对血清 3,5-,3,3-和 3-5-二碘甲状腺原氨酸和 3-单碘甲状腺原氨酸的影响。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. Faber
中科院分区：
文献类型：
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作者：
S. Jaedig;J. Faber
评估了完全禁食对碘甲腺原氨酸3，5-二碘甲腺原氨酸（3，5-T2）、3，3 'T2、3'，5 '-T2和3'-单碘甲腺原氨酸（3 '-T1）血清浓度的影响。14名肥胖妇女接受了4天的完全禁食。热量限制导致以下血清激素水平（前vs 3。日）：T4：103 vs 109 nmol/l（NS），T3：1.83 vs 1.24 nmol/l（p <0.01），rT3：0.276 vs 0.407 nmol/l（P <0.01），3.5-T2：70 pmol/l（NS），3.3'-T2：42 vs 39 pmol/l 3'，5'-T2：63 vs 93 pmol/l（P <0.01），3'-T1：60 vs 116 pmol/l（P <0.01）。所有受试者每天分次给予200 g（800 kcal，3350 kJ）d-葡萄糖，连续2天。再喂养倾向于使改变的碘甲腺原氨酸浓度正常化，并且无论是通过口服（n = 7）还是静脉途径给予葡萄糖都没有差异。可以得出这样的结论：人类饥饿伴随着T2和3 'T1外周代谢的深刻变化。口服或静脉注射d-葡萄糖对甲状腺激素代谢的影响似乎没有质的差异。
The effect of complete fasting on the serum concentrations of the iodothyronines 3,5-diiodothyronine (3,5-T2), 3,3'T2, 3', 5'-T2 and 3'-monoiodothyronine (3'-T1) was evaluated. Fourteen obese women underwent a complete fasting for 4 days. Caloric restriction resulted in the following serum hormone levels (before vs 3. day): T4: 103 vs 109 nmol/l (NS), T3: 1.83 vs 1.24 nmol/l (p less than 0.01), rT3: 0.276 vs 0.407 nmol/l (P less than 0.01), 3.5-T2: 70 pmol/l (NS), 3.3'-T2: 42 vs 39 pmol/l (p less than 0.01), 3',5'-T2: 63 vs 93 pmol/l (P less than 0.01), and 3'-T1 60 vs 116 pmol/l (P less than 0.01). All subjects were refed with 200 g (800 kcal, 3350 kJ) d-glucose per day in divided doses for 2 days. Refeeding tended to normalize the changed iodothyronine concentrations and there was no difference whether the glucose was administered by the oral (n = 7) or the intravenous route. In can be concluded that starvation in man is accompanied by profound changes in peripheral metabolism of the T2's and 3'T1. There seems to be no qualitative difference of the effect on the thyroid hormone metabolism of d-glucose administered by the oral or the intravenous route.