A Simple Quantitative Method for Analyzing Electrographic Status Epilepticus in Rats
A Simple Quantitative Method for Analyzing Electrographic Status Epilepticus in Rats
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DOI：
10.1152/jn.91062.2008
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发表时间：
2009-03-01
影响因子：
2.5
通讯作者：
Dudek, F. E.
中科院分区：
文献类型：
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作者：
Lehmkuhle, M. J.;Thomson, K. E.;Dudek, F. E.
Lehmkuhle MJ，Thomson KE，Scheerlinck P，Pouliot W，Greger B，Dudek FE.大鼠癫痫持续状态电图的简易定量分析方法。神经生理学杂志101：1660-1670，2009年。首次发表于2009年1月7日; doi：10.1152/jn.91062.2008。电描记癫痫持续状态（ESE）是一种由反复癫痫发作组成的医疗紧急情况，可能导致死亡或严重脑损伤。癫痫可以在ESE后发展。ESE的属性（例如。例如，在一个实施例中，持续时间和强度）是可变的，因为是推定的治疗性治疗的效果。因此，一种直接的方法来量化ESE的不同组成部分将有利于研究人员和临床医生。选择接近伽马波段的频率范围用于从EEG中提取癫痫相关活动。该滤波策略减少了电生理记录中的运动伪影和其他噪声源，从而增加了EEG尖峰活动的信噪比。使用能量算子量化EEG尖峰，并用八阶多项式建模。在匹罗卡品诱导的ESE的苯二氮卓类耐药大鼠模型中，用这种方法和其他方法分析各种药物抑制ESE的功效，
Lehmkuhle MJ, Thomson KE, Scheerlinck P, Pouliot W, Greger B, Dudek FE. A simple quantitative method for analyzing electrographic status epilepticus in rats. J Neurophysiol 101: 1660-1670, 2009. First published January 7, 2009; doi:10.1152/jn.91062.2008. Electrographic status epilepticus (ESE) is a medical emergency consisting of repetitive seizures and may result in death or severe brain damage. Epilepsy can develop following ESE. The properties of ESE (e. g., duration and intensity) are variable, as are the effects of putative therapeutic treatments. Therefore a straightforward method to quantify different components of ESE would be beneficial for both researchers and clinicians. A frequency range close to the gamma band was selected for extraction of seizure-related activity from the EEG. This filtering strategy reduced motion artifacts and other noise sources in the electrophysiological recordings, thus increasing the signal-tonoise ratio of the EEG spike activity. EEG spiking was quantified using an energy operator and modeled by an eighth-order polynomial. In a benzodiazepine-resistant rat model of pilocarpine-induced ESE, the efficacy of various pharmaceutical agents at suppressing ESE was analyzed with this and other methods on data collected for