Synaptic Integration in Tuft Dendrites of Layer 5 Pyramidal Neurons: A New Unifying Principle
Synaptic Integration in Tuft Dendrites of Layer 5 Pyramidal Neurons: A New Unifying Principle
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DOI：
10.1126/science.1171958
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发表时间：
2009-08-07
期刊：
影响因子：
56.9
通讯作者：
Schiller, Jackie
中科院分区：
文献类型：
--
作者：
Larkum, Matthew E.;Nevian, Thomas;Schiller, Jackie
簇状树突是支配新皮质第5层锥体神经元的反馈输入的主要靶点，但其性质尚不清楚。我们报告了在细小的远端簇状树突中存在N-甲基-D-天冬氨酸(NMDA)峰，否则不支持钙峰的启动。直接测量和计算机模拟都表明，NMDA峰是远端突触输入导致神经元放电的主要机制，并为到达簇状突触的自上而下输入的复杂并行处理提供了底物。这些数据导致了一种新的统一的锥体神经元整合观点，即所有细小的树突，基生和簇状，通过募集相对于固定的顶端钙和轴体钠结合点的NMDA受体通道，在局部整合输入。
Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5 pyramidal neurons, but their properties remain obscure. We report the existence of N-methyl-D-aspartate (NMDA) spikes in the fine distal tuft dendrites that otherwise did not support the initiation of calcium spikes. Both direct measurements and computer simulations showed that NMDA spikes are the dominant mechanism by which distal synaptic input leads to firing of the neuron and provide the substrate for complex parallel processing of top-down input arriving at the tuft. These data lead to a new unifying view of integration in pyramidal neurons in which all fine dendrites, basal and tuft, integrate inputs locally through the recruitment of NMDA receptor channels relative to the fixed apical calcium and axosomatic sodium integration points.