Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice
Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice
复制标题
具有多酶活性的普鲁士蓝纳米酶可减少小鼠结肠炎
DOI：
10.1021/acsami.8b10345
复制
发表时间：
2018
影响因子：
9.5
通讯作者：
Chen Hangrong
中科院分区：
文献类型：
--
作者：
Zhao Jiulong;Cai Xiaojun;Gao Wei;Zhang Linlin;Zou Duowu;Zheng Yuanyi;Li Zhaoshen;Chen Hangrong
活性氧（ROS）的过度产生是炎症性肠病（IBD）进展的核心，这可能是潜在的治疗靶点。普鲁士蓝（PB）纳米粒子具有良好的生物安全性，可作为人工纳米酶，有效清除活性氧。迄今为止，尚未开发和利用基于PB的纳米材料来治疗IBD。本研究通过一种简单有效的方法，构建了具有良好生理稳定性和生物安全性的聚乙烯吡咯烷酮修饰普鲁士蓝（PPB）纳米粒。制备的PPBs具有清除ROS和抑制促炎细胞因子的能力，通过静脉给药显著减轻小鼠结肠炎，而没有明显的副作用。该报告证明了PB基纳米药物对活体动物IBD的保护作用，为IBD患者提供了希望和潜在的替代治疗选择。
The overproduction of reactive oxygen species (ROS) is central to the progression of inflammatory bowel disease (IBD), which may be the potential therapeutic target. Prussian blue (PB) nanoparticles with good biosafety can act as an artificial nanozyme, effectively scavenging ROS. To date, PB-based nanomaterials have not been developed and utilized for treatment of IBD. In this study, poly(vinylpyrrolidone)-modified Prussian blue (PPB) nanoparticles are constructed with good physiological stability and biosafety by a simple and efficient method. The prepared PPBs with capabilities of scavenging ROS and inhibiting proinflammatory cytokine significantly reduce colitis in mice without distinct side effects via intravenous administration. This report provides a demonstration of the protective effect of PB-based nanomedicine against IBD in living animals, offering hope and a potential alternative treatment option for patients suffering from IBD.