Birthweight and the risk for type 2 diabetes mellitus in adult women
Birthweight and the risk for type 2 diabetes mellitus in adult women
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DOI：
10.7326/0003-4819-130-4_part_1-199902160-00005
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发表时间：
1999-02-16
影响因子：
39.2
通讯作者：
Manson, JE
中科院分区：
文献类型：
--
作者：
Rich-Edwards, JW;Colditz, GA;Manson, JE
背景资料：以前的报告提出了出生体重和2型糖尿病mellitus.Objective之间的关联：探讨出生体重和2型糖尿病之间的关联在一个大的队列的成年妇女，考虑到潜在的解释因素，在儿童和成人life.Design：队列研究。研究对象：69526名参加护士健康研究的妇女，她们在基线时没有糖尿病，并在1992年的问卷中报告了她们自己的出生体重。测量方法：1976 ~ 1992年确诊的2型糖尿病2123例。结果：低出生体重儿与2型糖尿病的危险性增加有关。校正后的相对危险度表明，出生体重与2型糖尿病风险之间呈倒J形相关。然而，在调整成人体重指数和母亲糖尿病史后，整个出生体重范围内的负相关变得明显;与对照组相比，按出生体重类别递增的相对危险度为1.83（95% CI，1.55 - 2.16）出生体重小于5.0 lb，1.76（CI，1.49 - 2.07）出生体重5.0 - 5.5 lb，1.23（CI，1.11 - 1.37）出生体重5.6 - 7.0 lb，0.95出生体重为8.6 - 10.0 lb的受试者Ct值为0.82 - 1.10，出生体重超过10 lb的受试者Ct值为0.83（CI值为0.63 - 1.07）（趋势P < 0.001）。调整种族，儿童的社会经济地位，和成年生活方式因素并没有实质上改变这种关联。出生体重与2型糖尿病风险之间的关联在母亲无糖尿病史的妇女中最强。结论：出生体重与成年期2型糖尿病风险呈负相关。检查产前营养和其他潜在的子宫内决定因素的出生体重和2型糖尿病的风险可能会产生新的方法来预防2型糖尿病。
Background: Previous reports have suggested an association between birthweight and type 2 diabetes mellitus.Objective: To investigate the association between birthweight and type 2 diabetes in a large cohort of adult women, taking into account potential explanatory factors in childhood and adult life.Design: Cohort study. Birthweight was ascertained at the end of follow-up.Setting: The Nurses' Health Study, a cohort of 121701 U.S. women born from 1921 to 1946 who have been followed since 1976.Participants: 69526 women in the Nurses' Health Study who were free of diabetes at baseline and reported their own birthweight on the 1992 questionnaire.Measurement: 2123 cases of confirmed type 2 diabetes diagnosed from 1976 to 1992.Results: Low birthweight was associated with increased risk for type 2 diabetes. Age-adjusted relative risks suggested a reverse J-shape association between birthweight and risk for type 2 diabetes. However, after adjustment for adult body mass index and maternal history of diabetes, an inverse association across the entire range of birthweight became apparent; compared with the reference group, relative risks by ascending birthweight category were 1.83 (95% CI, 1.55 to 2.16) for birthweight less than 5.0 Ib, 1.76 (CI, 1.49 to 2.07) for birthweight 5.0 to 5.5 Ib, 1.23 (CI, 1.11 to 1.37) for birthweight 5.6 to 7.0 Ib, 0.95 (Ct, 0.82 to 1.10) for birthweight 8.6 to 10.0 Ib, and 0.83 (CI, 0.63 to 1.07) for birthweight of more than 10 lb (P for trend < 0.001). Adjustment for ethnicity, childhood socioeconomic status, and adult lifestyle factors did not substantially alter this association. The association between birthweight and risk for type 2 diabetes was strongest among women whose mothers had no history of diabetes.Conclusions: Birthweight is inversely associated with risk for type 2 diabetes during adulthood. Examination of prenatal nutrition and other potential in utero determinants of both birthweight and risk for type 2 diabetes may yield new means to prevent type 2 diabetes.