Chronic pancreatitis: Report from a multicenter Italian survey (PANCROINFAISP) on 893 patients
Chronic pancreatitis: Report from a multicenter Italian survey (PANCROINFAISP) on 893 patients
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DOI：
10.1016/j.dld.2008.07.316
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发表时间：
2009-04-01
影响因子：
4.5
通讯作者：
Cavallini, G.
中科院分区：
文献类型：
--
作者：
Frulloni, L.;Gabbrielli, A.;Cavallini, G.
背景。意大利尚无慢性胰腺炎的数据。目的。评估慢性胰腺炎患者的人口统计学、临床、诊断和治疗方面。患者和方法。 2000年至2005年期间前瞻性招募符合条件的患者。收集了有关人口统计数据、生活方式危险因素、家族和临床史、相关因素（酒精、自身免疫、十二指肠壁囊性营养不良、梗阻、基因突变）、伴随疾病、诊断结果以及药理学、内窥镜和手术治疗的信息。结果。 893 名患者（74% 为男性，平均年龄 53.7 +/- 15.2 岁）接受了评估。 519/859 名患者 (60%) 饮酒，555/840 (66%) 吸烟。饮酒和吸烟之间存在很强的正相关性（R = 0.53；每天摄入 80 克酒精，持续 5 年以上），在 300 名患者 (34%) 中被认为是最重要的危险因素。 238 例 (27%) 患有梗阻，82 例 (9%) 患有酒精和梗阻，34 例 (4%) 患有自身免疫。 55 例（6%）患有十二指肠壁/沟囊性营养不良胰腺炎，36 例（4%）发生基因突变，148 例（17%）无（特发性）。 287 名患者 (33%) 被诊断出胆结石，329 名患者 (38%) 接受了胆囊切除术。 547/879 名患者 (62%) 被诊断出胰腺钙化。 273 名患者（31%）接受了胰腺手术。 371 名患者 (42%) 接受了内镜下乳头括约肌切开术。分别有 373/834 (45%) 和 275,1885 名患者 (31%) 发现外分泌和内分泌功能不全。结论。在意大利观察到酒精滥用频率出乎意料地低，并且出现了新的慢性胰腺炎相关危险因素。 (C) 2008 Editrice Gastroenterologica Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。
Background. No data on chronic pancreatitis in Italy are available yet.Aim. To evaluate demographic, clinical, diagnostic and therapeutic aspects in patients suffering from chronic pancreatitis.Patients and methods. Eligible patients were prospectively enrolled from 2000 to 2005. Information concerning demographic data, lifestyle risk factors, family and clinical history, associated factors (alcohol, autoimmunity, cystic dystrophy of the duodenal Wall. Obstruction, genetic mutations) concomitant diseases, diagnostic findings, and pharmacological, endoscopic and surgical therapy were gathered.Results. 893 patients (74% males, mean age 53.7 +/- 15.2 years) were evaluated. 519/859 patients (60%) were drinkers and 555/840 (66%) were smokers. A strong positive correlation between drinking and cigarette consumption (R=0.53; p80g of alcohol/day for more than 5 years) was considered the most important risk factor in 300 patients (34%). obstruction in 238 (27%), alcohol and obstruction in 82 (9%), autoimmunity in 34 (4%). cystic dystrophy of the duodenal wall/groove pancreatitis in 55 (6%), gene mutations in 36 (4%), and none (idiopathic) in 148 (17%). Bile stones were diagnosed in 287 patients (33%) and cholecystectomy was performed in 329 patients (38%). Pancreatic calcifications were diagnosed in 547/879 patients (62%). Pancreatic surgery was performed in 273 patients (31%). Endoscopic sphincterotomy was performed in 371 patients (42%). Exocrine and endocrine insufficiency were found, respectively, in 373/834 (45%) and 275,1885 patients (31%).Conclusions. An unexpected low frequency of alcohol abuse and new emerging associated risk factors for chronic pancreatitis were observed in Italy. (C) 2008 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.