FLASH, a component of the FAS-CAPSASE8 apoptotic pathway, is directly regulated by Hoxb4 in the notochord
FLASH, a component of the FAS-CAPSASE8 apoptotic pathway, is directly regulated by Hoxb4 in the notochord
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DOI：
10.1016/j.ydbio.2003.09.030
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发表时间：
2004-01-01
影响因子：
2.7
通讯作者：
El-Kadi, ASM
中科院分区：
文献类型：
--
作者：
Morgan, R;Nalliah, A;El-Kadi, ASM
Hox基因是一个含有同源结构域的转录因子家族，在发育过程中赋予位置同一性。虽然它们的调控和功能已被广泛研究，但对其下游靶基因知之甚少。在这里，我们表明，Hoxb 4直接诱导FLASH的表达在脊索的神经形成后的胚胎。FLASH是FAS-CAPSASE 8凋亡途径的一个组成部分，阻断其活性或HoxN的活性可防止脊索中的凋亡。(C)2003年爱思唯尔公司All rights reserved.
The Hox genes are a family of homeodomain-containing transcription factors that confer positional identity during development. Although their regulation and function have been extensively studied, very little is known of their downstream target genes. Here we show that Hoxb4 directly induces the expression of FLASH in the notochord of embryos after neurulation. FLASH is a component of the FAS-CAPSASE8 apoptotic pathway, and blocking its activity, or that of HoxN, prevents apoptosis in the notochord. (C) 2003 Elsevier Inc. All rights reserved.