EVOLUTION OF CANCER OF COLON AND RECTUM
EVOLUTION OF CANCER OF COLON AND RECTUM
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DOI：
10.1002/cncr.2820360944
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发表时间：
1975-01-01
期刊：
影响因子：
6.2
通讯作者：
MORSON, BC
中科院分区：
文献类型：
--
作者：
MUTO, T;BUSSEY, HJR;MORSON, BC
结肠和直肠腺瘤的恶性潜能因其大小、组织学类型和上皮异型性的分级而异。腺瘤性息肉通常很小，恶性可能性低，而具有绒毛结构的肿瘤通常较大，癌变率高得多。严重的非典型性在绒毛腺瘤中比在腺瘤性息肉中更常见。有证据表明，大多数结肠癌和直肠癌是通过息肉-癌序列进化而来的，尽管大多数腺瘤在正常的成人寿命期间不会癌变。强调了息肉-癌序列的缓慢进化。本文讨论了息肉-癌序列对癌症预防方案设计和大肠癌病因学研究的意义。
The malignant potential of adenomas of the colon and rectum varies with size, histological type and grade of epithelial atypia. The adenomatous polyp is usually small and has a low malignant potential, whereas tumors with a villous structure are usually larger and have a much higher cancer rate. Severe atypia is more common in villous adenomas than in adenomatous polyps. Evidence is presented which suggests that most cancers of the colon and rectum have evolved through the polyp‐cancer sequence although the majority of adenomas do not become cancerous during a normal adult life span. The slow evolution of the polyp‐cancer sequence is stressed. The implications of the polyp‐cancer sequence for the design of cancer prevention programmes and the study of the aetiology of large bowel cancer are discussed.