Minimal redistribution of pulmonary blood flow with exercise in racehorses.
Minimal redistribution of pulmonary blood flow with exercise in racehorses.
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赛马运动时肺血流量的最小重新分配。
DOI：
10.1152/jappl.1996.81.3.1062
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Hlastala,MP
中科院分区：
文献类型：
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作者：
Bernard,SL;Glenny,RW;Erickson,HH;Fedde,MR;Polissar,N;Basaraba,RJ;Hlastala,MP
我们使用15微米的荧光微球测定了纯种赛马（n = 4）在休息时和运动水平增加（最大耗氧量的34%、59%和90%）时肺血流量的空间分布。马被杀死后，将肺部冲洗掉血液，取出，在总肺容量下空气干燥，并切成等重力平面，以系统的方式对其进行采样以进行三维重建。测量荧光以定量血流。平均肺血流异质性（表示为变异系数）不随运动水平的增加而变化[36.2 +/- 16.4（静息）至26.9 +/- 6.8%（奔马）; P =不显著]。从静息状态到高强度运动状态，超过70%的肺血流变化是由固定的空间模式决定的。在休息和运动状态下，马的肺血流量变化的30%是由于再分布。大部分流量重新分布是由于在运动期间以90%的最大耗氧量（流量梯度为0.20 ml）增加到肺背侧区域的流量。min-1.cm-1; P = 0.04）。
We determined the spatial distribution of pulmonary blood flow at rest and during increasing levels of exercise (34, 59, and 90% of maximal oxygen consumption) in Thoroughbred racehorses (n = 4) using 15-microns fluorescent microspheres. After the horses were killed, the lungs were flushed free of blood, removed, air-dried at total lung capacity, and sliced into isogravitational planes, which were sampled in a systematic fashion for three-dimensional reconstruction. The fluorescence was measured for quantification of blood flow. Mean pulmonary blood flow heterogeneity (expressed as a coefficient of variation) did not change with increasing exercise levels [36.2 +/- 16.4 (rest) to 26.9 +/- 6.8% (gallop); P = not significant]. Greater than 70% of pulmonary blood flow variation across rest to high-exercise states is determined by a fixed spatial pattern. Thirty percent of the variation in pulmonary blood flow seen in horses over rest and exercising states is due to redistribution. The majority of flow redistribution was due to flow increasing to the dorsal region of the lung during exercise at 90% of maximal oxygen consumption (a flow gradient of 0.20 ml. min-1.cm-1 up the lung; P = 0.04).