What are the consequences of freezing the anomeric effect in nucleosides?
What are the consequences of freezing the anomeric effect in nucleosides?
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冻结核苷异头效应会产生什么后果？
DOI：
10.1093/nass/nrn275
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Kelley,JamesA
中科院分区：
文献类型：
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作者：
Marquez,VictorE;Sun,Guangyu;Siddiqui,MaqboolA;Lee,Yi-Chien;BarchiJr,JosephJ;Filippov,IgorV;Landsman,NicklausA;Kelley,JamesA
在两个氧双环-[3.1.0]正己烷核苷(1和2)中，从理论和实验上研究了决定反常效应是否起作用的氧的孤对轨道取向冻结的后果。结果表明，这些分子的性质存在显著差异，这与N_2→σ*离域的大小有关。
The consequences of freezing the orientation of the oxygen’s lone pair orbitals —which determines whether the anomeric effect is operative or not— were studied theoretically and experimentally in two oxobicyclo-[3.1.0]hexane nucleosides (1 and 2). The results showed significant differences in the properties of these molecules, which correlated with the magnitude of the n2 → σ* delocalization.