Synonymous codon bias is related to gene length in Escherichia coli: Selection for translational accuracy?
Synonymous codon bias is related to gene length in Escherichia coli: Selection for translational accuracy?
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DOI：
10.1093/oxfordjournals.molbev.a025646
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发表时间：
1996-07-01
影响因子：
10.7
通讯作者：
EyreWalker, A
中科院分区：
文献类型：
--
作者：
EyreWalker, A
在大肠杆菌基因中，同义密码子偏向的水平与基因长度呈正相关，这些基因被认为是以相似的水平表达的；这些基因的产物以等摩尔量存在于多聚体蛋白质中。本文认为，这种正相关可能是由于翻译过程中为避免误解而进行的选择造成的。由于生产蛋白质的成本与其长度成正比，因此在较长的基因中，有利于提高准确性的密码子的选择应该更多，因此，较长的基因应该具有更高的同义密码子偏向。研究还表明，同义密码子的使用存在变异，这种变异与表达水平、基因长度、氨基酸组成或染色体位置无关。这种变异与翻译精确度的选择是一致的，但可能有其他来源。
The level of synonymous codon bias is shown to be positively correlated to gene length in Escherichia coli genes which are thought to be expressed at similar levels; these are genes whose products are present in multimeric proteins in equimolar amounts. It is argued that the positive correlation could be caused by selection to avoid missense errors during translation. Since the cost of producing a protein is proportional to its length, selection in favor of codons which increase accuracy should be greater in longer genes, and long genes should therefore have higher synonymous codon bias. It is also shown that there is variation in synonymous codon use which is independent of either expression level, gene length, amino acid composition, or chromosomal location. This variation is consistent with selection for translational accuracy but may have other origins.