Screening for Osteoporosis in Older Men: Operating Characteristics of Proposed Strategies for Selecting Men for BMD Testing
Screening for Osteoporosis in Older Men: Operating Characteristics of Proposed Strategies for Selecting Men for BMD Testing
复制标题
DOI：
10.1007/s11606-017-4153-4
复制
发表时间：
2017-11-01
影响因子：
5.7
通讯作者：
Ensrud, Kristine E.
中科院分区：
文献类型：
--
作者：
Diem, Susan J.;Peters, Katherine W.;Ensrud, Kristine E.
背景：选择男性进行骨密度(BMD)测试以筛查骨质疏松症的最佳方法尚不确定。目的：比较选择老年男性进行骨密度测试的策略。设计：前瞻性队列研究。研究对象：在美国四个地点，共有4043名70岁的社区男性。主要测量：使用双能X射线骨密度仪(DXA)测量全髋部、股骨颈和腰椎的骨密度。无骨密度的骨质疏松症自我评估工具(OST)和骨折风险评估工具(FRAX)的灵敏度、特异度、阳性预测值、阴性预测值、阳性似然比、阴性似然比和受试者工作曲线下面积(AUC)，以区分世界卫生组织(WHO)诊断标准定义的骨质疏松者和没有骨质疏松症的人，以及根据国家骨质疏松基金会(NOF)指南推荐和不推荐进行药物治疗的人。KEY结果：在队列中，216人(5.3%)有BMD T评分
BACKGROUND: The optimal approach for selecting men for bone mineral density (BMD) testing to screen for osteoporosis is uncertain.OBJECTIVE: To compare strategies for selecting older men for screening BMD testing.DESIGN: Prospective cohort study.PARTICIPANTS: A total of 4043 community-dwelling men aged >= 70 years at four US sites.MAIN MEASURES: BMD at the total hip, femoral neck, and lumbar spine using dual-energy x-ray absorptiometry (DXA). Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and area under the receiver operating curve (AUC) of the Osteoporosis Self-Assessment Tool (OST) and Fracture Risk Assessment Tool (FRAX) without BMD to discriminate between those with and without osteoporosis as defined by World Health Organization (WHO) diagnostic criteria, and between those recommended and not recommended for pharmacologic therapy based on the National Osteoporosis Foundation (NOF) guidelines.KEY RESULTS: Among the cohort, 216 (5.3%) had a BMD T-score