Self-Reported Sleep Disordered Breathing as Risk Factor for Mortality in the Elderly.
Self-Reported Sleep Disordered Breathing as Risk Factor for Mortality in the Elderly.
复制标题
自我报告睡眠呼吸障碍是老年人死亡的危险因素。
DOI：
10.1016/j.jstrokecerebrovasdis.2016.03.008
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Stern,Yaakov
中科院分区：
文献类型：
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作者：
Tsapanou,Angeliki;Gu,Yian;O'Shea,Deirdre;Manly,Jennifer;Schupf,Nicole;Scarmeas,Nikolaos;Stern,Yaakov
BackgroundThis study aims to examine the association between self-reported sleep disordered breathing（SDB）（“awake short of breath or with a headache”）and mortality in a large and ethnically diverse group of community-dwelling elderly people.MethodsA total of 1288 participants，65 years and older，were examined longitudinally.使用医学结局研究睡眠量表评估睡眠问题，检查睡眠障碍、打鼾、醒来时呼吸急促或头痛、睡眠充足和睡眠嗜睡。考克斯回归分析被用来检查睡眠问题和死亡率之间的关系。年龄、性别、教育、种族和体重指数作为协变量。在进一步的分析中，我们包括高血压，糖尿病，心脏病，中风作为额外的协variations.ResultsThe参与者随访长达6年（平均值= 2.9，标准差= 1.1），和239（18.6%）参与者在随访期间死亡。在未校正的模型中，首次访视时SDB与死亡率相关（风险比[HR] = 1.37; 95%置信区间[CI] 1.21-1.55;P< .0001）。校正所有协变量后，SDB与死亡率之间的关系仍然显著（HR = 1.48; 95%CI 1.29-1.70;P< .0001）。与加勒比海-西班牙裔血统的参与者有较高的风险mortality.ConclusionsOur结果表明，SDB是一个大的和种族多样性的老年人群体的死亡率的危险因素，独立的人口和临床因素。需要进一步的研究来检查这种关联的潜在机制。
BackgroundThis study aimed to examine the association between self-reported sleep disordered breathing (SDB) (“awaken short of breath or with a headache”) and mortality in a large and ethnically diverse group of community-dwelling elderly people.MethodsA total of 1288 participants, 65 years and older, were examined longitudinally. Sleep problems were estimated using the Medical Outcomes Study Sleep Scale examining sleep disturbance, snoring, awaken short of breath or with a headache, sleep adequacy, and sleep somnolence. Cox regression analysis was used to examine the association between sleep problems and mortality. Age, gender, education, ethnicity, and body mass index were included as covariates. In further analyses we included hypertension, diabetes, heart disease, and stroke as additional covariates.ResultsThe participants were followed for up to 6 years (mean = 2.9, standard deviation = 1.1), and 239 (18.6%) participants died during the follow-up. In unadjusted models, SDB at the initial visit was associated with mortality (hazard ratio [HR] = 1.37; 95% confidence interval [CI] 1.21-1.55;P< .0001). After adjusting for all the covariates, the relationship between SDB and mortality remained significant (HR = 1.48; 95% CI 1.29-1.70;P< .0001). Participants with Caribbean-Hispanic ancestry have higher risk for mortality.ConclusionsOur results suggest that SDB is a risk factor for mortality in a large and ethnically diverse group of older adults, independent of demographic and clinical factors. Further research is needed to examine the underlying mechanisms of this association.