Adult rabbit offspring of mothers with secondary hypertension have increased blood pressure
Adult rabbit offspring of mothers with secondary hypertension have increased blood pressure
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DOI：
10.1161/01.hyp.0000052949.85257.8e
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发表时间：
2003-03-01
期刊：
影响因子：
8.3
通讯作者：
Anderson, WP
中科院分区：
文献类型：
--
作者：
Denton, KM;Flower, RL;Anderson, WP
先前存在的慢性高血压使多达5%的妊娠并发症，并与低出生体重婴儿的风险增加有关。研究表明，导致出生体重低的宫内不良环境与成年后心血管疾病（包括高血压）风险增加有关。在这项研究中，高血压母亲的后代的血压被随访到成年。在7只雌性家兔中诱导两肾一包高血压;另5只家兔进行假手术。4周后，将家兔交配，此时高血压组和假手术组的平均动脉压分别为118+/-3和87+/-5 mm Hg（P
Preexisting chronic hypertension complicates up to 5% of pregnancies and is associated with an increased risk of low-birth-weight babies. Studies suggest that an adverse intrauterine environment leading to low birth weight is linked to an increased risk of cardiovascular disease, including hypertension, in the adult. In this study, the blood pressure of offspring from mothers with hypertension were followed up into adulthood. Two-kidney, 1-wrapped hypertension was induced in 7 female rabbits; 5 other rabbits underwent sham surgery. Four weeks later, rabbits were mated, at which time mean arterial pressure was 118+/-3 and 87+/-5 mm Hg in the hypertensive and sham groups, respectively (P