A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation
A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation
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DOI：
10.1016/j.exer.2007.01.015
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发表时间：
2007-05-01
影响因子：
3.4
通讯作者：
Kublin, Claire L.
中科院分区：
文献类型：
--
作者：
Zoukhri, Driss;Macari, Elizabeth;Kublin, Claire L.
我们实验室的新兴研究表明，白细胞介素-1（IL-1）家族成员在损害泪腺功能中起主要作用。在这里，我们已经扩大了我们的调查，以观察白细胞介素-1对水泪液的生产，泪腺分泌，泪腺组织学，腺泡和导管细胞增殖的影响。我们证明，一个单一的注射IL-1到泪腺抑制神经以及激动剂诱导的蛋白质分泌导致泪液分泌减少。同时，IL-1注射诱导严重但可逆的（7-13天）炎症反应，导致泪腺腺泡上皮细胞破坏。最后，我们证明，随着炎症反应消退，泪腺分泌和泪液分泌恢复到正常水平，腺泡和导管上皮细胞增殖增加。我们的工作揭示了IL-1对泪腺功能和小鼠泪腺潜在再生能力的新作用。(C)2007爱思唯尔有限公司出版
Emerging studies from our laboratory demonstrate that interleukin-1 (IL-1) family members play a major role in impairing lacrimal gland functions. Here we have extended our investigations to observe the effects of IL-1 on aqueous tear production, lacrimal gland secretion, lacrimal gland histology, and acinar and ductal cell proliferation. We demonstrate that a single injection of IL-1 into the lacrimal glands inhibited neurally- as well as agonist-induced protein secretion resulting in decreased tear output. Meanwhile, IL-1 injection induced a severe, but reversible (7-13 days), inflammatory response that led to destruction of lacrimal gland acinar epithelial cells. Finally, we demonstrate that as the inflammatory response subsided and lacrimal gland secretion and tear production returned to normal levels, there was increased proliferation of acinar and ductal epithelial cells. Our work uncovers novel effects of IL-1 on lacrimal gland functions and the potential regenerative capacity of the mouse lacrimal gland. (C) 2007 Published by Elsevier Ltd.