PREDICTORS OF RETINAL PIGMENT EPITHELIUM TEAR DEVELOPMENT AFTER TREATMENT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION USING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
PREDICTORS OF RETINAL PIGMENT EPITHELIUM TEAR DEVELOPMENT AFTER TREATMENT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION USING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
复制标题
使用扫频光学相干断层扫描血管造影治疗新生血管年龄相关性黄斑变性后视网膜色素上皮撕裂发展的预测因素
DOI：
10.1097/iae.0000000000003426
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Tsujikawa Akitaka
中科院分区：
文献类型：
--
作者：
Yasuhara Satoshi;Miyata Manabu;Ooto Sotaro;Tamura Hiroshi;Ueda-Arakawa Naoko;Uji Akihito;Muraoka Yuki;Miyake Masahiro;Takahashi Ayako;Wakazono Tomotaka;Yamashiro Kenji;Tsujikawa Akitaka
目的：本研究的目的是探讨预测视网膜色素上皮（RPE）撕裂的发展后，治疗新生血管性年龄相关性黄斑变性使用扫描源光学相干断层扫描angiography.Methods：这项前瞻性研究包括152治疗初治的眼睛与新生血管性年龄相关性黄斑变性没有高度近视，随访1年后治疗。合格的眼睛被分为有或没有RPE泪液发展的眼睛。它们以1：2的比例匹配。分别从光学相干断层扫描血管造影和OCT面部图像测量脉络膜新生血管（CNV）和RPE脱离（色素上皮脱离[PED]）的面积。光学相干断层扫描血管造影的具体参数代表CNV status.Results的状态进行了分析：8（5.3%）的152只眼睛发展的RPE眼泪（RPE眼泪组）。匹配后，分析16只无RPE撕裂的眼睛（非RPE撕裂组）。RPE撕裂组CNV/PED面积比值低于非RPE撕裂组（P= 0.007）。RPE撕裂组的PED面积更宽（P= 0.008），PED高度更高（P= 0.04）。光学相干断层扫描血管造影的具体参数没有显着差异两groups.Conclusion：新生血管性年龄相关性黄斑变性与预处理广泛的PED，高PED，和小CNV面积相对于PED面积治疗后的RPE撕裂发展的风险很高。然而，CNV状态可能没有关联。
Purpose:The purpose of this study was to investigate the predictors of retinal pigment epithelium (RPE) tear development after treatment for neovascular age-related macular degeneration using swept source optical coherence tomography angiography.Methods:This prospective study included 152 treatment-naïve eyes with neovascular age-related macular degeneration without high myopia that were followed up for 1 year after treatment. Eligible eyes were classified into eyes with or without RPE tear development. They were matched in a 1: 2 ratio. The areas of choroidal neovascularization (CNV) and RPE detachment (pigment epithelial detachment [PED]) were measured from optical coherence tomography angiography and OCT en face images, respectively. The optical coherence tomography angiography–specific parameters representing CNV status were analyzed.Results:Eight (5.3%) of the 152 eyes developed RPE tears (RPE tear group). After matching, 16 eyes without RPE tears were analyzed (non-RPE tear group). The ratio of the CNV/PED area was lower in the RPE tear group than that in the non-RPE tear group (P= 0.007). The PED area was broader (P= 0.008), and PED height was greater in the RPE tear group (P= 0.04). Optical coherence tomography angiography–specific parameters did not differ between the two groups.Conclusion:Neovascular age-related macular degeneration with pretreatment broad PED, high PED, and small CNV area relative to the PED area has a high risk of RPE tear development after therapy. However, CNV status may not have an association.