Neutrophil-Lymphocyte ratio and Platelet-Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus
Neutrophil-Lymphocyte ratio and Platelet-Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus
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DOI：
10.1016/j.dsx.2016.12.021
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发表时间：
2017-11-01
影响因子：
10
通讯作者：
Gunay, Murat
中科院分区：
文献类型：
--
作者：
Mertoglu, Cuma;Gunay, Murat
目的：慢性炎症在糖尿病的发生和进展及其并发症的发病机制中起着核心作用。中性粒细胞-淋巴细胞比值（NLR）和血小板-淋巴细胞比值（PLR）是亚临床炎症的指标。平均血小板体积（MPV）是血小板功能指标之一。我们研究了 NLR、PLR 和 MPV 与糖尿病前期和 2 型糖尿病的关联，并确定这些是否是可靠的诊断标志物。 材料和方法：参与者分为四组； 1：糖耐量正常，2：糖耐量受损（糖尿病前期），3：通过OGTT新诊断的糖尿病。 4：组先前被诊断为糖尿病且无并发症。比较各组之间的结果。结果：所有组之间的 NLR (p = 0.004) 和 PLR (p = 0.021) 值均存在显着差异。与正常组 (1.37 +/- 0.69) 相比，糖尿病前期组 (1.60 +/- 0.85)、首次诊断糖尿病组 (1.58 +/- 0.78) 和明确糖尿病组 (2.07 +/- 0.95) 的 NLR 值显着较高（平均值，SD）。与正常组（100.55+/-48.14）相比，糖尿病前期组（90.35+/-44.34）和初诊糖尿病组（86.38+/-45.24）PLR值显着较低，但明确糖尿病组显着较高（122.45+/-37.43）。各组间MPV值无显着性差异。结论：糖尿病前期和糖尿病患者炎症标志物NLR显着升高。 PLR 在糖尿病前期和糖尿病早期阶段显着降低，但在糖尿病晚期阶段则升高。 NLR 和 PLR 值可能是糖尿病前期和糖尿病的可靠预测指标。 (C) 2016 年印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Aims: Chronic inflammation plays a central role in the development and progression of diabetes, and in the pathogenesis of its complications. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are indicators of subclinical inflammation. Mean platelet volume (MPV) is one of the platelet function indices. We investigated the association of NLR, PLR and MPV with prediabetes and type 2 diabetes mellitus and determine whether or not these are reliable markers for diagnosis.Materials and methods: Participants were divided into four groups; 1: normal glucose tolerance, 2: impaired glucose tolerance (prediabetic), 3: newly diagnosed diabetic by OGTT. 4: group is previously diagnosed diabetic without complication. Outcomes were compared between groups.Results: There are significant differences between all groups in NLR (p = 0.004) and PLR (p = 0.021) values. NLR values are significantly higher in prediabetic (1.60 +/- 0.85), firstly diagnosed diabetic (1.58 +/- 0.78) and clear diabetic (2.07 +/- 0.95) groups compared to normal group (1.37 +/- 0.69) (mean, SD). PLR values are significantly lower in prediabetic (90.35 +/- 44.34) and firstly diagnosed diabetic (86.38 +/- 45.24) groups compared to normal group (100.55 +/- 48.14) but significantly higher in clear diabetic group (122.45 +/- 37.43). There are no significant differences between all groups in MPV values.Conclusion: Inflammation marker NLR significantly increases in prediabetic and diabetic patients. PLR significantly decreases in prediabetes and early stages of diabetes but increases in later stages. NLR and PLR values may be reliable predictive markers in prediabetes and diabetes mellitus. (C) 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.