Additive effect of the mutations in the β3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome
Additive effect of the mutations in the β3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome
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DOI：
10.1038/sj.ijo.0802562
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发表时间：
2004-03-01
影响因子：
4.9
通讯作者：
Lee, JH
中科院分区：
文献类型：
--
作者：
Kim, OY;Cho, EY;Lee, JH
目的：分析β 3-肾上腺素能受体突变的影响（β 3-AR）基因和/或解偶联蛋白3（UCP 3）基因启动子对患有冠状动脉疾病（CAD）或代谢综合征的超重肥胖受试者轻度减重后体脂分布和血糖控制的影响。设计：-300千卡/天轻度减重计划的临床干预研究，为期12周。受试者：共224名患有CAD或代谢紊乱的超重肥胖受试者，细分为以下四类：（1）野生型（TT-CC，n=73）;（2）仅UCP 3启动子变体（TT-CT/TT，n=90）;（3）仅β 3-AR变体（TA/AA-CC，n=29）;（4）两种变体（TA/AA-CT/TT，n=32）。体重指数（BMI）、血压、卡路里摄入量、体脂分布、血糖、胰岛素、游离脂肪酸，减肥前后的C肽和脂质。结果：12周后，所有受试者的体重均减轻了初始体重的约5%。尽管体重减轻相似，但在“野生型”组中观察到L1和L4水平的腹部脂肪组织减少最多（P
Objective: To analyze the effects of the mutations in the beta3-adrenoceptor (beta3-AR) gene and/or uncoupling protein3 (UCP3) gene promoter on body fat distribution and glycemic control after mild weight reduction in overweight-obese subjects with coronary artery disease (CAD) or metabolic syndrome.Design: Clinical intervention study of the -300 kcal/day mild weight reduction program for 12 weeks.Subjects: A total of 224 overweight-obese subjects with CAD or metabolic disorder, subdivided into the following four categories: (1) wild type (TT-CC, n=73); (2) only UCP3 promoter variant (TT-CT/TT, n=90); (3) only beta3-AR variant (TA/AA-CC, n=29); (4) both variants (TA/AA-CT/TT, n=32).Measurement: Body mass index (BMI), blood pressure, calorie intakes, body fat distribution, serum glucose, insulin, free fatty acids, C-peptide and lipids before and after weight reduction.Results: After 12 weeks, all subjects lost approximately 5% of their initial body weight. Despite similar weight reduction, the highest decreases in abdominal adipose tissue at both L1 and L4 levels were observed in the 'wild-type' group (P